乳腺癌ER、AR表达与术前MRI征象的相关性分析  

Analysis of Correlation between Expression of ER and AR and Preoperative MRI Signs in Breast Cancer

作　　者：张士朋 姚立国 王彦龙 曹静 张旭霞 张志强 苟芳丽 彭梅娟[1] 谢一婧 朱大林[1] ZHANG Shi-peng;YAO Li-guo;WANG Yan-long;CAO Jing;ZHANG Xu-xia;ZHANG Zhi-qiang;GOU Fang-li;PENG Mei-juan;XIE Yi-jing;ZHU Da-lin(Medical Imaging Center of Gansu Maternal and Child-care Hospital(Gansu Provincial CentralHospital),LanZhou 730050,Gansu Province,China;Radiography Department of Lanzhou University Second Hospital,LanZhou 730030,GansuProvince,China;The Second Clinical Medical College of Lanzhou University,LanZhou 730000,Gansu Province,China)

机构地区：[1]甘肃省妇幼保健院(甘肃省中心医院)医学影像中心,甘肃兰州730050 [2]兰州大学第二医院放射影像科,甘肃兰州730030 [3]兰州大学第二临床医学院,甘肃兰州730000

出　　处：《中国CT和MRI杂志》2024年第2期85-88,共4页Chinese Journal of CT and MRI

基　　金：甘肃省自然科学基金(21JR11RA170)。

摘　　要：目的探讨乳腺癌ER、AR表达与术前MRI征象的相关性。方法收集甘肃省妇幼保健院2019年1月至2022年1月乳腺癌患者共计234例,依据术后免疫组化将其分为ER、AR双表达组、共计155例,ER、AR非双表达组、共计79例,采用Sperman及两独立样本t检验对ER、AR双表达与术前MRI征象进行单因素相关性分析,筛选存在统计学意义的MRI征象并进行多因素Logistic相关性分析。结果乳腺癌AR、ER表达与肿瘤形态之间差异无统计学意义(均P>0.05),与瘤体直径、环形强化及瘤周水肿之间差异具有统计学意义(均P<0.05),乳腺癌AR、ER双表达者肿瘤直径更小,环形强化及瘤周水肿更少见,二元Logistic回归分析表明环形强化(OR=0.421,P=0.041),瘤周水肿(OR=0.505,P=0.025)与乳腺癌AR、ER双表达相关。结论术前MRI征象与乳腺癌AR、ER双表达有较好的相关性,乳腺癌AR、ER双表达者瘤周水肿、环形强化少见,肿瘤组织学分级低,侵袭性弱。Objective To investigate the correlation between expression of ER and AR in breast cancer and preoperative MRI signs.Methods A total of 234 cases of breast cancer patients from June 2020 to March 2022 in Gansu Women's and Children's Health Hospital were collected and divided into ER and AR expression group(n=155)and non of both ER and AR expression group(n=79)according to postoperative immunohistochemistry.The single-factor correlation analysis between ER and AR expression and preoperative MRI signs was performed using Sperman and two independent samples t-test,and the statistically significant MRI signs were screened and the multi-factor Logistics correlation analysis was performed.Results There were no significant differences between AR and ER expression and tumor morphology in breast cancer(all P>0.05),but there were significant differences with tumor body diameter,annular enhancement,tumor edge and peritumoral edema(all P<0.05).For AR and ER expression patients in breast cancer,the tumor diameter was smaller,annular enhancement and peritumoral edema were less common.The binary Logistic regression analysis showed that:annular enhancement(OR=0.421,P=0.041),and peritumoral edema(OR=0.505,P=0.025)were the independent predictors of AR and ER expression in breast cancer.Conclusion Preoperative MRI signs have a good correlation with expression of AR and ER in breast cancer.Peritumoral edema and annular enhancementburr-like changes are rare in patients with expression of AR and ER in breast cancer,and the tumor has low biological activity and weak invasion.

关 键 词：乳腺癌 雌激素受体 雄激素受体 磁共振成像 

分 类 号：R737.9[医药卫生—肿瘤] R445.2[医药卫生—临床医学]