大豆提取物-α-倒捻子素复合物的制备及其抗氧化活性  

Preparation and Antioxidant Activity of Soybean Extract-α-Mangostin Complex

作　　者：张余[1,2] 王鹏 王雪峰 郭若曦 张蕾 王艳 ZHANG Yu;WANG Peng;WANG Xuefeng;GUO Ruoxi;ZHANG Lei;WANG Yan(Tianjin University of Traditional Chinese Medicine,Tianjin 301617,China;Haihe Laboratory of Modern Chinese Medicine,Tianjin 301600,China;Tianjin Shangmei Cosmetics Co.,Ltd.,Tianjin 300385,China)

机构地区：[1]天津中医药大学,天津301617 [2]现代中医药海河实验室,天津301600 [3]天津尚美化妆品有限公司,天津300385

出　　处：《香料香精化妆品》2024年第1期67-73,164,共8页Flavour Fragrance Cosmetics

基　　金：国家自然科学基金青年科学基金项目(编号81602773)。

摘　　要：为提高难溶化合物α-倒捻子素溶解性,采用摇瓶-冷冻干燥法制备大豆提取物-α-倒捻子素复合物并对其进行结构表征和体外抗氧化活性评价。结果表明,在最佳工艺即大豆提取物质量浓度200 mg/mL、60℃、16 h、220 r/min下制得的复合物中α-倒捻子素溶解度为379.014μg/mL;复合物平均粒径为(1.21±0.015) nm,分布均一,且大豆提取物与α-倒捻子素之间可能通过氢键缔合;大豆提取物与α-倒捻子素具有协同抗氧化作用,大豆提取物-α-倒捻子素复合物对DPPH自由基和ABTS自由基清除作用强于同质量浓度的α-倒捻子素。In order to improve the solubility ofα-mangostin,the soybean extract-α-mangostin complex was established by shaking flask-freeze-drying method,and its structure was characterized and its antioxidant activity was evaluated in vitro.The results showed that the solubility ofα-mangostin was 379.014μg/mL under the optimum preparation conditions of soybean extract 200 mg/mL,60℃,16 h and 220 r/min.The average particle size of the complex was(1.21±0.015)nm,with uniform distribution,and the association between soybean extract andα-mangostin might be achieved through hydrogen bond.In addition,soybean extract andα-mangostin had synergistic antioxidant activity,and the scavenging effect of soybean extract-α-mangostin complex on DPPH and ABTS free radicals was stronger than that ofα-mangostin at the same concentration.

关 键 词：大豆提取物 α-倒捻子素 复合物 溶解度 抗氧化 

分 类 号：TQ28[化学工程—有机化工]