IKBKE在乙型肝炎病毒相关肝癌组织中的表达及临床意义  

Expression of IKBKE in hepatitis B virus-related hepatocellular carcinoma tissues and its clinical significance

作　　者：刘大成[1] 阮圆 LIU Dacheng;RUAN Yuan(Jining Second People′s Hospital,Jining 272000,Shandong,P.R.China)

机构地区：[1]济宁市第二人民医院,山东济宁272000

出　　处：《滨州医学院学报》2024年第2期117-121,共5页Journal of Binzhou Medical University

摘　　要：目的探究IKBKE在乙型肝炎病毒相关肝癌(HBV-HCC)组织中的表达及其与临床特征和预后的相关性。方法通过组织芯片免疫组织化学染色方法来检测HBV-HCC患者的癌组织和癌旁组织中B细胞编码κ轻链多肽基因抑制激酶E(IKBKE)的蛋白表达;整理并分析患者的一般资料、临床体征及病理报告结果,检测相关的血液指标;使用Pearson相关性分析比较IKBKE在肝细胞肝癌组织中的表达及其与患者的一般临床资料、临床体征、血液指标、病理结果和预后的相关性。结果该研究发现,在HBV相关的肝癌患者中,IKBKE的蛋白表达在癌组织中的表达水平显著高于正常组织,高表达组的生存时间明显低于低表达组。此外,IKBKE表达与肝硬化程度呈负相关,与TFF3、pCEA和Ki67等指标呈正相关。结论IKBKE、TFF3、pCEA和Ki67的联合检测有助于预测HBV相关肝癌的预后。Objective To investigate the expression of IKBKE in hepatitis B virus-related hepatocellular carcinoma(HBV-HCC)tissues and its correlation with clinical features and prognosis.Methods Tissue microarray immunohistochemistry was used to detect the protein expression of IKBKE(inhibitor of nuclear factor kappa-B kinase subunit epsilon)in cancer tissues and adjacent non-cancerous tissues of HBV-HCC patients.General information,clinical symptoms,and pathological reports of patients were collected and analyzed,along with relevant blood indicators.Pearson correlation analysis was conducted to compare the expression of IKBKE in hepatocellular carcinoma tissues with the general clinical data,clinical symptoms,blood indicators,pathological results,and prognosis of the patients.Results This study showed that the protein expression of IKBKE was significantly higher in cancer tissues than in normal tissues in HBV-related liver cancer patients,and the high-expression group exhibited significantly lower overall survival than the low-expression group.Furthermore,IKBKE expression was negatively correlated with the degree of liver cirrhosis and positively correlated with indicators such as TFF3,pCEA,and Ki67.Conclusion The combined detection of IKBKE,TFF3,pCEA,and Ki67 can help predict the prognosis of HBV-related liver cancer.

关 键 词：B细胞编码κ轻链多肽基因抑制激酶E 乙型肝炎病毒相关肝癌 临床特征 预后 

分 类 号：R735.7[医药卫生—肿瘤]