高同型半胱氨酸血症脑梗死患者的相关特征分析  

Analysis of Related Characteristics of Cerebral Infarction Patients with Hyperhomocysteinemia.

作　　者：石奕虹 李晶[1] 王敏[1] SHI Yihong;LI Jing;WANG Min(First Teaching Hospital of Tianjin University of Traditional Chinese Medicine,National Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion,Tianjin 300193,China)

机构地区：[1]天津中医药大学第一附属医院、国家中医针灸临床医学研究中心,300193

出　　处：《医学研究杂志》2024年第1期41-44,共4页Journal of Medical Research

基　　金：国家自然科学基金资助项目(81674056);天津市自然科学基金资助项目(18JCYBJC94200)。

摘　　要：目的探讨脑梗死患者中高同型半胱氨酸血症者的常见症状和伴随疾病特征及其影响因素的相关性分析。方法将血同型半胱氨酸≥15μmol/L的患者列为高同型半胱氨酸血症脑梗死组(H组),共151例;血同型半胱氨酸<15μmol/L的患者列为血同型半胱氨酸正常脑梗死组(N组),共86例,比较两者的症状差异及其影响因素。结果在脑梗死患者中,H组患者的年龄大(P=0.049)、男性多(P=0.002),具有吸烟史(P=0.025)、糖尿病(P=0.008)、高脂血症(P=0.034)、叶酸缺乏(P=0.002)并伴随认知障碍(P=0.009)、语言障碍(P=0.043)的比例高。通过二元Logistic回归分析,得到年龄(P=0.023)、糖尿病(P=0.018)、叶酸缺乏(P=0.026)、认知障碍(P=0.019)均为高同型半胱氨酸血症的相关影响因素。结论合并高同型半胱氨酸血症的脑梗死患者表现为老年,多数合并患有糖尿病、叶酸缺乏和认知障碍。Objective To investigate the common symptoms and associated disease characteristics of hyperhomocysteinemia in cerebral infarction patients and the correlation analysis of influencing factors.Methods A total of 151 participants with blood homocysteine≥15μmol/L and 86 participants with blood homocysteine<15μmol/L were identified as the hyperhomocysteinemia with cerebral infarction group(H group)and the normal cerebral infarction group(N group),respectively.The symptoms and influence factors in the two groups were compared.Results Among cerebral infarction patients,patients in H group were older(P=0.049),more male(P=0.002),had a history of smoking(P=0.025),diabetes(P=0.008),hyperlipidemia(P=0.034),folate deficiency(P=0.002)and associated cognitive impairment(P=0.009)and language barrier(P=0.043).Binary Logistic regression analysis showed that age(P=0.023),diabetes(P=0.018),folate deficiency(P=0.026),and cognitive impairment(P=0.019)were independent related factors of increased blood homocysteine level.Conclusion Cerebral infarction patients with hyperhomocysteinemia are elderly,and most of them have diabetes,folate deficiency,and cognitive impairment.

关 键 词：脑梗死 高同型半胱氨酸血症 叶酸缺乏 

分 类 号：R743.3[医药卫生—神经病学与精神病学]