黏蛋白在胃食管反流病发病机制中的作用研究进展  

Research progress on the role of mucin in the pathogenesis of gastroesophageal reflux disease

作　　者：齐梅 周悦 张梦圆 方盛泉[1] Qi Mei;Zhou Yue;Zhang Mengyuan;Fang Shengquan(Department of Gastroenterology,Yueyang Hospital of Integrative Medicine,Shanghai University of Traditional Chinese Medicine,Shanghai 200080,China)

机构地区：[1]上海中医药大学附属岳阳中西医结合医院消化内科,上海200080

出　　处：《新医学》2024年第2期92-95,共4页Journal of New Medicine

基　　金：上海市中医药三年行动计划重点项目[ZY(2021-2023)-0302];上海市卫健委临床专项(202140171);上海市自然科学基金面上项目(20ZR1459300)。

摘　　要：胃食管反流病(GERD)是临床常见的一种治疗具有挑战性的反复发作性疾病。长期烧心和(或)反流症状严重影响患者日常生活质量。研究表明,GERD与食管抗反流屏障受损密切相关,黏蛋白(MUC)即为该屏障主要组成成分。该文主要对MUC在GERD发病机制中的作用及其影响因素作一综述。Gastroesophageal reflux disease(GERD)is a common recurrent disease and the treatment of GERD is challenging.Chronic heartburn and/or reflux symptoms seriously affect the quality of daily life of patients.Studies have shown that GERD is closely associated with the impairment of anti-reflux barrier of the esophagus,of which mucin(MUC)is the main component.The role of MUC in the pathogenesis of GERD and influencing factors were reviewed in this article.

关 键 词：黏蛋白 胃食管反流 发病机制 影响因素 

分 类 号：R571[医药卫生—消化系统]