Pathogenic contribution of cholesteryl ester accumulation in the brain to neurodegenerative disorders  

作　　者：Michiko Shirane 

机构地区：[1]Department of Molecular Biology,Graduate School of Pharmaceutical Sciences,Nagoya City University,Nagoya,Japan

出　　处：《Neural Regeneration Research》2024年第10期2099-2100,共2页中国神经再生研究（英文版）

摘　　要：Cholesteryl esters(CEs) have been increasingly implicated in neurodegenerative disorders such as Alzheimer's disease(AD).Alois Alzheimer noted three prominent neuropathologic features in his original analysis of the AD brain:senile plaques,neurofibrillary tangles,and lipid granule accumulation.Senile plaques,which are aggregates of amyloid-beta(Aβ),and neurofibrillary tangles,which are aggregates of phosphorylated tau,have been regarded as more consistent characteristics of the AD brain compared with lipid granule accumulation and thus have been studied more intensively(Foley,2010).

关 键 词：ESTERS ESTER cholesteryl 

分 类 号：R741.02[医药卫生—神经病学与精神病学]