m^(6)A甲基化修饰在女性生殖系统中的作用及研究进展  

The role and research progress of m^(6)A methylation modification in the female reproductive system

作　　者：陶晨玥 苑秋悦 周东杰 张萍萍 周罗晶[5] 王丽萍[5] TAO Chen-yue;YUAN Qiu-yue;ZHOU Dong-jie;ZHANG Ping-ping;ZHOU Luo-jing;WANG Li-ping(School of Nursing,School of Public Health,Yangzhou University,Yangzhou 225001;School of Pharmacy,China Medical University,Shenyang 110000;Clinical Medical College,Yangzhou University,Yangzhou 225001;Department of Gynecology and Obstetrics,Yangzhou Maternal and Child Health Care Hospital of Jiangsu Province,Yangzhou 225001;Science and Technology Division,Northern Jiangsu People’s Hospital,Yangzhou 225001)

机构地区：[1]扬州大学护理学院·公共卫生学院,扬州225001 [2]中国医科大学药学院,沈阳110000 [3]扬州大学临床医学院,扬州225001 [4]江苏省扬州市妇幼保健院妇产科,扬州225001 [5]江苏省苏北人民医院科技处,扬州225001

出　　处：《生殖医学杂志》2024年第2期254-258,共5页Journal of Reproductive Medicine

基　　金：国家自然科学基金青年项目(82001512);江苏省科技计划面上项目(BK20211118);江苏省卫生健康委医学科研面上项目(M2021044)。

摘　　要：N6-甲基腺苷(m^(6)A)修饰是RNA中最丰富的表观遗传修饰方式,动态可逆地调控各种生命过程。近期研究表明,m^(6)A甲基化修饰及其调控因子在卵泡发育过程中必不可少,m^(6)A甲基化修饰失调会导致女性生殖系统疾病,包括多囊卵巢综合征、早发性卵巢功能不全、卵巢衰老甚至宫颈癌、子宫内膜癌和卵巢癌等妇科恶性肿瘤。本文对m^(6)A甲基化修饰作用于卵泡发育过程和女性生殖系统疾病发生发展过程的相关研究进展作一综述,系统介绍m^(6)A甲基化酶及其调控因子在卵泡发育和生殖系统疾病发生发展中的作用机制,旨在为女性生殖系统疾病预防、早期诊断和治疗提供新的检测方法和研究方向。N6-methyladenosine(m^(6)A)modification is the most abundant epigenetic modification in RNA,which dynamically and reversibly regulates various life processes.Recent studies have shown that m^(6)A modifiers and regulators are essential for follicular development.Dysregulation of m^(6)A modification can lead to diseases of the female reproductive system,including polycystic ovary syndrome,primary ovarian insufficiency,ovarian aging and even gynecological malignancies such as cervical,endometrial and ovarian cancer.This article reviews the research progress of m^(6)A methylation in the process of follicular development and the occurrence and development of female reproductive system diseases,and systematically introduces the mechanism of m^(6)A methylase and its regulators in the process of follicular development as well as the occurrence and development of female reproductive system diseases,in order to provide new detection methods and research directions for the prevention,early diagnosis and treatment of female reproductive system diseases.

关 键 词：N6-甲基腺苷甲基化 卵泡发育 表观遗传 女性生殖系统疾病 

分 类 号：R394.3[医药卫生—医学遗传学]