Photostimulation of lymphatic clearance ofβ‑amyloid from mouse brain:a new strategy for the therapy of Alzheimer’s disease  

作　　者：Dongyu Li Hao Lin Silin Sun Shaojun Liu Zhang Liu Yuening He Jingtan Zhu Jianyi Xu Oxana Semyachkina‑Glushkovskaya Tingting Yu Dan Zhu 

机构地区：[1]Britton Chance Center for Biomedical Photonics-MoE Key Laboratory for Biomedical Photonics,Wuhan National Laboratory for Optoelectronics-Advanced Biomedical Imaging Facility,Huazhong University of Science and Technology,Wuhan 430074,China [2]School of Optical Electronic Information,Huazhong University of Science and Technology,Wuhan 430074,China [3]Department of Biology,Saratov State University,Saratov 410012,Russia

出　　处：《Frontiers of Optoelectronics》2023年第4期179-190,共12页光电子前沿（英文版）

基　　金：supported by the National Natural Science Foundation of China(NSFC)(Grant Nos.61860206009,81961138015,62375096,82372012,62375095,62105113 and 82001877);Key Research and Development Project of Hubei Province(No.2022BCA023);the Innovation Fund of WNLO;SGO was supported by grant from the Russian Science Foundation 23-75-30001.

摘　　要：Alzheimer’s disease(AD)is an age-related neurodegenerative disorder that poses a signifcant burden on socio-economic and healthcare systems worldwide.However,the currently available therapy of AD is limited,and new strategies are needed to enhance the clearance ofβ-amyloid(Aβ)protein and improve cognitive function.Photobiomodulation(PBM)is a noninvasive and efective therapeutic method that has shown promise in treating various brain diseases.Here,we demonstrate that 1267-nm PBM signifcantly alleviates cognitive decline in the 5xFAD mouse model of AD and is safe as it does not induce a signifcant increase in cortical temperature.Moreover,with the combination of 3D tissue optical clearing imaging and automatic brain region segmentation,we show that PBM-mediated reductions of Aβplaques in diferent subregions of prefrontal cortex and the hippocampus are diferent.The PBM-induced lymphatic clearance of Aβfrom the brain is associated with improvement of memory and cognitive functions in 5xFAD mice.Our results suggest that the modulation of meningeal lymphatic vessels(MLVs)should play an important role in promoting Aβclearance.Collectively,this pilot study demonstrates that PBM can safely accelerate lymphatic clearance of Aβfrom the brain of 5xFAD mice,promoting improvement of neurocognitive status of AD animals suggesting that PBM can be an efective and bedside therapy for AD.

关 键 词：Photostimulation-Meningeal lymphatic vessels Amyloid-βclearance Alzheimer's disease 

分 类 号：R749.16[医药卫生—神经病学与精神病学]