放射性脑损伤的研究进展  

Advances in research on radiation⁃induced brain injury

作　　者：曾丽晶 夏煌 陈钰昕 林佩悦 杨晶 曾文艺 李小波[1] 徐本华[1] 郑榕 Zeng Lijing;Xia Huang;Chen Yuxin;Lin Peiyue;Yang Jing;Zeng Wenyi;Li Xiaobo;Xu Benhua;Zheng Rong(Department of Radiation Oncology,Fujian Medical University Union Hospital,Fujian Key Laboratory of Intelligent Imaging and Precision Radiotherapy for Tumors,Clinical Research Center for Radiology and Radiotherapy of Fujian Province(Digestive,Hematological and Breast Malignancies),Fuzhou 350001,China;School of Medical Imaging of Fujian Medical University,Fuzhou 350122,China)

机构地区：[1]福建医科大学附属协和医院放疗科,福建省肿瘤智能影像与精准放疗重点实验室,福建省消化、血液系统与乳腺恶性肿瘤放射与治疗临床医学研究中心,福州350001 [2]福建医科大学医学影像学院,福州350122

出　　处：《中华放射医学与防护杂志》2024年第1期65-71,共7页Chinese Journal of Radiological Medicine and Protection

基　　金：国家自然科学基金面上项目(82173452);福建医科大学附属协和医院优秀青年人才培育项目(2022XH034);福建医科大学大学生创新创业训练计划资助项目(YX2023009)。

摘　　要：原发性或转移性脑部恶性肿瘤患者接受放射治疗时,会引起脑组织功能和形态学变化,导致放射性脑损伤,并且其发病机制尚无统一定论,现有的研究进展和治疗方案有待阐明和完善。本综述从血管损伤、炎症反应、神经元功能障碍、胶质细胞损伤以及肠道微生物方面讨论放射性脑损伤的发病机制,以及治疗与预防的相关研究进展,旨在为放射性脑损伤的研究和临床诊治提供参考和理论依据。Radiotherapy can cause functional and morphological changes in the brain tissues of patients with primary or metastatic malignant brain tumors,leading to radiation-induced brain injury.However,the pathogenesis of radiation-induced brain injury has not yet been unanimously determined,and its research advances and treatment protocols are yet to be elucidated and improved.In this study,we explore the pathogenesis of radiation-induced brain injury from the perspective of vascular injury,inflammatory reactions,neuronal dysfunction,glial cell injury,and gut microbiota and reviewed the advances in research on its treatment and prevention.The purpose is to provide a reference and theoretical basis for the research and clinical diagnosis and treatment of radiation-induced brain injury.

关 键 词：放射性脑损伤 放射治疗 星形胶质细胞 肠道微生物 

分 类 号：R730.55[医药卫生—肿瘤]