CYP3A基因家族在胃癌中的研究进展  

Research progress regarding CYP3A gene family in gastric cancer

作　　者：贾祺 丁青松 邵康梅 党建中 张凡[2,3] JIA Qi;DING Qingsong;SHAO Kangmei;DANG Jianzhong;ZHANG Fan(Second Clinical Medical School,Lanzhou University,Lanzhou 730030;Department of Surgical Oncology,Second Hospital,Lanzhou University,Lanzhou 730030;Frontiers Science Center for Rare Isotopes,Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第二临床医学院,兰州730030 [2]兰州大学第二医院肿瘤外科,兰州730030 [3]兰州大学稀有同位素前沿科学中心,兰州730000

出　　处：《中南大学学报（医学版）》2023年第12期1874-1881,共8页Journal of Central South University ：Medical Science

基　　金：兰州大学中央高校基本科研业务费专项资金资助(lzujbky-2023-stlt01);兰州大学第二医院“萃英科技创新”计划项目(CY2022-YB-A04,CY2023-MS-B17);兰州大学第二医院“萃英学子科研培育计划”(CYXZ2021-14)。

摘　　要：细胞色素P450(cytochrome P450,CYP)家族的主要成员CYP3A是人体中重要的药物代谢酶之一。CYP3A包括4种基因亚型(CYP3A4、CYP3A5、CYP3A7和CYP3A43),参与人体60%的药物代谢过程。其不仅在正常组织中广泛分布,还在多种肿瘤组织中显著高表达。近年来,CYP3A因参与慢性萎缩性胃炎发展至胃癌的过程、胃癌化学治疗药物的差异性代谢及耐药等而备受关注,靶向CYP3A基因介导的酶前药物为胃癌的治疗提供了新的思路,有望成为胃癌诊治的新靶点。Cytochrome P450 family 3 subfamily A(CYP3A),a major member of cytochrome P450(CYP)family,is one of the most important drug metabolizing enzymes in human.CYP3A includes 4 gene subtypes(CYP3A4,CYP3A5,CYP3A7,and CYP3A43),which is involved in 60%of drug metabolism in the human.It is not only widely distributed in normal tissues,but also significantly overexpressed in various tumor tissues.Recently,CYP3A has attracted great attention due to its involvement in the progression from chronic atrophic gastritis to gastric cancer,as well as the differential metabolism and resistance of chemotherapeutic drugs.Targeting CYP3A gene mediated-prodrug provides new ideas for the treatment of gastric cancer and is expected to become a new target for the diagnosis and treatment of gastric cancer.

关 键 词：细胞色素P450 细胞色素P4503A 细胞色素P4503A4 胃癌 肿瘤 药物代谢酶 

分 类 号：R735.2[医药卫生—肿瘤]