肿瘤性骨软化症继发甲状旁腺功能亢进症1例  

A case of hyperparathyroidism secondary to tumor-induced osteomalacia

作　　者：杨幼波[1] 金萍[1] 张淑婷 陈科[1] 何红晖[1] 莫朝晖[1] 袁晶晶[1] YANG Youbo;JIN Ping;ZHANG Shuting;CHEN Ke;HE Honghui;MO Zhaohui;YUAN Jingjing(Department of Endocrinology,Third Xiangya Hospital,Central South University,Changsha 410013;Department of Clinical Laboratory,Third Xiangya Hospital,Central South University,Changsha 410013,China)

机构地区：[1]中南大学湘雅三医院内分泌科,长沙410013 [2]中南大学湘雅三医院检验科,长沙410013

出　　处：《中南大学学报（医学版）》2023年第12期1937-1943,共7页Journal of Central South University ：Medical Science

摘　　要：肿瘤性骨软化症(tumor-induced osteomalacia,TIO)是一种因肿瘤组织分泌过量成纤维细胞生长因子23(fibroblast growth factor 23,FGF23)而引起肾脏排磷增多的代谢性骨病,是一种罕见的副肿瘤综合征。中南大学湘雅三医院2021年9月收治1例罕见的TIO患者,该患者的肿瘤位于舌骨体,并且继发了三发性甲状旁腺功能亢进症。在舌骨体肿瘤切除后,患者的症状并未好转,随后对其进行左侧甲状旁腺切除,患者的低磷血症才逐渐改善。发源于舌部肿瘤的TIO十分少见,同时继发三发性甲状旁腺亢进的病例更是罕见,本报告有助于加深对TIO的了解,并为TIO的诊断和治疗提供参考。Tumor-induced osteomalacia(TIO)is a rare paraneoplastic syndrome in which tumor-induced osteochondrosis is a metabolic bone disease caused by increased renal excretion of phosphorus due to excessive secretion of fibroblast growth factor 23(FGF23)by tumor tissue.We report here a rare case of TIO in which the tumor was found in the hyoid body and the patient had tertiary hyperparathyroidism.The patient’s symptoms did not improve after removal of the tumor from the hyoid body,and the patient’s hypophosphatemia was gradually improved after subsequent removal of the left parathyroid gland.TIO derived from the tongue tumor is very rare,and also subsequent tertiary hyperparathyroidism is even rarer.This report helps to improve the understanding of TIO and provides reference in the diagnosis and treatment of TIO.

关 键 词：肿瘤性骨软化症 甲状旁腺功能亢进症 磷酸盐尿性间叶肿瘤 成纤维细胞生长因子23 

分 类 号：R582.1[医药卫生—内分泌] R730.6[医药卫生—内科学]