团体社会技能康复训练对慢性精神分裂症长期住院患者疗效  

Effect of group social skill rehabilitation training on long-term chronic schizophrenia inpatients

作　　者：朱峰莉 毛锶佳 杨巧菲 吴琴芳 冯敏 潘鑫[2] ZHU Feng-li;MAO Si-jia;YANG Qiao-fei;WU Qin-fang;FENG-Min;PAN Xin(Department of Psychiatry,The Fourth People's Hospital Of Haining,Haining 314400,China)

机构地区：[1]海宁市第四人民医院精神科,314400 [2]湖州市第三人民医院

出　　处：《临床精神医学杂志》2024年第1期35-38,共4页Journal of Clinical Psychiatry

基　　金：湖州市公益性应用研究项目(2019GY26)。

摘　　要：目的:探讨基于本地文化的团体社会技能康复训练对慢性精神分裂症长期住院患者疗效。方法:选取海宁市第四人民医院精神科2020年1月至2022年2月收治的80例慢性精神分裂症长期住院患者,按随机数字表法分为研究组40例和对照组40例,研究组常规治疗基础上加上基于本地文化的团体社会技能康复训练,对照组给予常规治疗;治疗前和治疗3个月后应用阴性症状评定量表(SANS)、阳性症状评定量表(SAPS)评定疗效,并检测血清白介素-6(IL-6)水平。结果:研究组和对照组干预前SANS、SAPS评分比较,差异均无统计学意义(P均>0.05);研究组干预前后SANS评分的差值比对照组更大,两组差异有统计学意义(P<0.01),团体社会技能康复训练对阴性症状有中等度效应;研究组干预前后IL-6水平差值和SANS差值、IL-6水平差值和SAPS差值均存在显著相关性,而对照组无相关性。结论:慢性精神分裂症长期住院患者采用团体社会技能康复训练可改善阴性症状,精神分裂症患者可能存在血清白介素-6水平异常。Objective:To explore the effect of group social skill rehabilitation training based on local culture on long-term hospitalized patients with chronic schizophrenia.Method:80 long-term inpatients with chronic schizophrenia admitted to the Department of Psychiatry at the Fourth People's Hospital of Haining City from January 2020 to February 2022 were enrolled and randomly divided into research group(n=40)and con-trol group(n=40)based on random number table.The research group received localized group social skill re-habilitation training on the basis of routine treatment,while the control group received routine treatment;Before and after 3 months’treatment,the efficacy was evaluated using the Negative Symptom Rating Scale(SANS)and Positive Symptom Rating Scale(SAPS),and serum interleukin-6(IL-6)levels were measured.Results:There was no significant difference between the SANS and SAPS scores before intervention between the study group and the control group(all P>0.05),and the difference between the SANS scores before and after the in-tervention in the study group was greater than that in the control group,and the difference between the two groups was significant(P<0.01),and group social skills rehabilitation training had a moderate effect on nega-tive symptoms.There were significant correlations between IL-6 level difference and SANS difference,IL-6 level difference and SAPS difference before and after intervention in the study group,while there was no correlation in the control group.Conclusion:Group social skill rehabilitation training can improve negative symptoms in long-term hospitalized patients with chronic schizophrenia,and serum IL-6 levels may dysregulated in schizo-phrenia patients.

关 键 词：团体社会技能 康复训练 慢性精神分裂症 长期住院患者 疗效 白介素-6 

分 类 号：R749.3[医药卫生—神经病学与精神病学]