非自杀性自伤的内分泌免疫研究进展  

Research progress in endocrine-immune for non-suicidal self-injury

作　　者：周洛慧 苏颖芮 柳绪珍[2] 孙静[2] ZHOU Luo-hui;SU Ying-rui;LIU Xu-zhen;SUN Jing(Nanjing Medical University,Nanjing 210029,China)

机构地区：[1]南京医科大学,210029 [2]南京医科大学附属脑科医院

出　　处：《临床精神医学杂志》2024年第1期78-80,共3页Journal of Clinical Psychiatry

基　　金：南京市卫生科技发展项目(YKK22141)

摘　　要：非自杀性自伤(NSSI)多发生在青少年和成年早期,与情绪相关疾病发生率增高及发展至难治性等相关,是自杀的重要危险因素。NSSI人群其内分泌和免疫发生一些变化,探讨NSSI发生的内分泌免疫机制,可能有助于NSSI早期预防与干预。本文从下丘脑-垂体-肾上腺轴(HPA轴)、下丘脑-垂体-甲状腺轴(HPT轴)、下丘脑-垂体-性腺轴(HPG轴)及免疫炎症与NSSI发生的相关研究进展作一综述。Non-suicidal self-injury(NSSI),being one of the most important suicide risk factors,mostly oc-cur in adolescent and early adulthood,which is related to the mood disorder and move forward to treatment re-sistant.People with NSSI have some changes in endocrine-immune.Exploring the mechanism on endocrine-im-mune for NSSI will help to earlier prevention and intervention.This article will review the research progress for NSSI on the following endocrine-immune aspects such as hypothalamic-pituitary-adrenal axis(HPA),hypotha-lamic-pituitary-thyroid axis(HPT),hypothalamic-pituitary-gonadal axis(HPG)and the immune inflammation.

关 键 词：非自杀性自伤 青少年及成年早期 下丘脑-垂体-肾上腺轴 下丘脑-垂体-甲状腺轴 下丘脑-垂体-性腺轴 免疫炎症 

分 类 号：R749.4[医药卫生—神经病学与精神病学]