膀胱大细胞淋巴瘤1例报告并文献复习  

Bladder large cell lymphoma:a case report and literature review

作　　者：汪浩 李步堂 迟辰斐 姜心诚 叶惟靖[2] 陈奇[2] 杨国良[2] 薛蔚[2] WANG Hao;LI Butang;CHI Chenfei;JIANG Xincheng;YE Weijing;CHEN Qi;YANG Guoliang;XUE Wei(Department of Urology,Hangzhou Bay Hospital,Ningbo 315336;Department of Urology,Renji Hospital Affiliated to Medical College of Shanghai Jiaotong University,Shanghai 200135,China)

机构地区：[1]宁波市杭州湾医院泌尿外科,浙江宁波315336 [2]上海交通大学医学院附属仁济医院泌尿外科,上海200135

出　　处：《现代泌尿外科杂志》2024年第2期122-125,共4页Journal of Modern Urology

基　　金：国家自然科学基金项目(No:82273288)。

摘　　要：目的通过分享1例膀胱原发的间变型淋巴瘤激酶(ALK)阴性间变大细胞淋巴瘤(ALK-ALCL)患者在宁波市杭州湾医院泌尿外科和血液科的诊疗过程,提高对ALK-ALCL的认识和诊治水平。方法回顾性分析该例患者的临床资料和诊疗过程,并结合文献复习探讨该疾病的发病特点、诊治方案和预后。结果该例患者为青少年男性,以反复肉眼血尿伴右侧腰痛为首发症状,影像学检查显示膀胱肿物,经膀胱肿瘤电切术予以减瘤,同时明确病理为ALK-ALCL,经过化疗及自体造血干细胞移植后患者病情持续缓解,且复查过程中肿瘤未见复发。结论膀胱原发的ALK-ALCL十分罕见,临床上容易误诊和漏诊,本例患者成功的诊疗经验可供临床参考。Objective To improve the understanding and diagnosis and treatment level of ALK negative anaplastic large cell lymphoma(ALK-ALCL)by sharing the diagnosis and treatment process of a patient with ALK-ALCL treated in Hangzhou Bay Hospital of Ningbo.Methods The clinical data and diagnosis and treatment process of the patient were retrospectively analyzed,and relevant literature was reviewed.Results The patient was a young male,with recurrent gross hematuria and right low back pain as the initial symptoms.Imaging examination indicated bladder tumor.After resection,the tumor was reduced and confirmed to be ALK-ALCL.After chemotherapy and autologous hematopoietic stem cell transplantation,the patient s condition continued to improve.During the follow-up,no recurrence was observed.Conclusion Primary ALK-ALCL in the bladder is very rare and prone to misdiagnosis and missed diagnosis in clinical practice.The successful diagnosis and treatment experience of this patient can provide clinical reference.

关 键 词：膀胱肿瘤 间变大细胞淋巴瘤 化疗 造血干细胞移植 

分 类 号：R737.14[医药卫生—肿瘤]