Osteomodulin downregulation is associated with osteoarthritis development  

作　　者：Jérémie Zappia Qiao Tong Renée Van der Cruyssen Frederique MFCornelis Cécile Lambert Tiago Pinto Coelho Juliane Grisart Erika Kague Rik JLories Marc Muller Dirk Elewaut Chrissy LHammond Christelle Sanchez Yves Henrotin 

机构地区：[1]MusculoSKeletal Innovative Research Lab,Center for Interdisciplinary Research on Medicines,Universitéde Liège,Liège,Belgium [2]School of Physiology,Pharmacology,and Neuroscience,University of Bristol,Bristol,UK [3]Department of Biomedical Molecular Biology,Ghent University,Ghent,Belgium [4]Laboratory for Molecular Immunology and Inflammation,Department of Rheumatology,Ghent University Hospital,Ghent,Belgium [5]Laboratory of Tissue Homeostasis and Disease,Skeletal Biology and Engineering Research Center,Department of Development and Regeneration,KU Leuven,Leuven,Belgium [6]Cardiovascular Sciences,Groupe Interdisciplinaire de Génoprotéomique Appliquée,Universitéde Liège,Liège,Belgium [7]Division of Nephrology,CHU of Liège,Universitéde Liège,Liège,Belgium [8]Artialis SA,Tour GIGA,CHU Sart-Tilman,Liège,Belgium [9]Division of Rheumatology,University Hospitals Leuven,Leuven,Belgium [10]Laboratoire d’Organogenèse et Régénération,Groupe Interdisciplinaire de Génoprotéomique Appliquée,Universitéde Liège,Liège,Belgium [11]Physical Therapy and Rehabilitation Department,Princess Paola Hospital,Vivalia,Marche-en-Famenne,Belgium

出　　处：《Bone Research》2023年第4期721-736,共16页骨研究（英文版）

基　　金：funded by the F.R.S.-FNRS for the “EOS: The Excellence of Science-Join-t-against-Osteoarthritis”, grant number 30480119;by a research grant from the Osteoarthritis Foundation and by the University of Liege (Fonds Léon Fredericq and Fonds Speciaux à la Recherche);funded by Versus Arthritis senior fellowship 21937。

摘　　要：Abnormal subchondral bone remodeling leading to sclerosis is a main feature of osteoarthritis(OA), and osteomodulin(OMD), a proteoglycan involved in extracellular matrix mineralization, is associated with the sclerotic phenotype. However, the functions of OMD remain poorly understood, specifically in vivo. We used Omd knockout and overexpressing male mice and mutant zebrafish to study its roles in bone and cartilage metabolism and in the development of OA. The expression of Omd is deeply correlated with bone and cartilage microarchitectures affecting the bone volume and the onset of subchondral bone sclerosis and spontaneous cartilage lesions. Mechanistically, OMD binds to RANKL and inhibits osteoclastogenesis, thus controlling the balance of bone remodeling. In conclusion, OMD is a key factor in subchondral bone sclerosis associated with OA. It participates in bone and cartilage homeostasis by acting on the regulation of osteoclastogenesis. Targeting OMD may be a promising new and personalized approach for OA.

关 键 词：METABOLISM CONCLUSION HOMEOSTASIS 

分 类 号：R684.3[医药卫生—骨科学]