非酒精性脂肪肝患者血清FGF21水平变化与颈动脉粥样硬化斑块发生的相关性  

The Correlation between Serum FGF21 Level and the Occurrence of Carotid Atherosclerotic Plaque in Patients with Non-alcoholic Fatty Liver Disease

作　　者：田宸骏 曹洁[2] 岳平[3] TIAN Chen-jun;CAO Jie;YUE Ping(The First Clinical Medical College,Lanzhou University,Lanzhou 730000,China;Department of Clinical Laboratory,The First Hospital of Lanzhou University,Lanzhou 730000,China;Department of General Surgery,The First Hospital of Lanzhou University,Lanzhou 730000,China)

机构地区：[1]兰州大学第一临床医学院,兰州730000 [2]兰州大学第一医院医学检验中心,兰州730000 [3]兰州大学第一医院普外科,兰州730000

出　　处：《微循环学杂志》2024年第1期63-66,77,共5页Chinese Journal of Microcirculation

摘　　要：目的:探讨非酒精性脂肪肝(NAFLD)患者血清成纤维细胞生长因子21(FGF21)水平变化及与颈动脉粥样硬化斑块发生的相关性。方法:选取2023-01-2023-09确诊的NAFLD患者131例,根据是否存在颈动脉粥样硬化斑块分为无斑块组(n=59)和斑块组(n=72),选取同期体检健康者39例为对照组。检测所有对象血清尿酸(UA)、低密度脂蛋白胆固醇(LDL-C)、小而密低密度脂蛋白胆固醇(sdLDL-C)、高密度脂蛋白胆固醇(HDL-C)、甘油三酯(TG)、总胆固醇(TC)和FGF21水平并比较组间差异。Logistic回归分析FGF21与NAFLD患者颈动脉粥样硬化斑块发生的相关性。结果:与对照组比较,无斑块组和斑块组患者UA、TC、TG、LDL-C、sdLDL-C和FGF21水平均升高,HDL-C水平降低(P<0.05或P<0.01);与无斑块组比较,斑块组LDL-C、sdLDL-C和FGF21升高(P<0.05或P<0.01)。Logistic回归分析显示,在充分调整协变量后,血清FGF21升高与NAFLD患者动脉粥样硬化斑块发生呈正相关。结论:血清FGF21是NAFLD患者颈动脉粥样硬化斑块发生的危险因素。Objective:To explore the correlation between fibroblast growth factor 21(FGF21)and the occurrence of carotid atherosclerotic plaques in patients with non-alcoholic fatty liver disease(NAFLD).Method:A total of 131 patients diagnosed with NAFLD from January 2023 to September 2023 were selected and divided into the plaque group and the no-plaque group based on the presence or absence of carotid atherosclerotic plaques.Additionally,39 healthy individuals undergoing routine check-ups at the same period were chosen as the control group.Serum levels of uric acid(UA),low-density lipoprotein cholesterol(LDL-C),small dense low-density lipoprotein cholesterol(sdLDL-C),high-density lipoprotein cholesterol(HDL-C),triglycerides(TG),total cholesterol(TC),and FGF21 were measured,and differences in these parameters were analyzed.Logistic regression analysis was employed to determine the correlation between serum FGF21 levels and the occurrence of carotid atherosclerotic plaques in NAFLD patients.Results:Compared to the control group,both the no-plaque and plaque groups showed increased levels of UA,TC,TG,LDL-C,sdLDL-C,and FGF21,while HDL-C levels were reduced(P<0.05 or P<0.01).Compared to the no-plaque group,the plaque group had higher levels of LDL-C,sdLDL-C,and FGF21,with these differences were statistically significant(P<0.05 or P<0.01).After adjusting for covariates,logistic regression analysis revealed that increased serum FGF21 levels were positively correlated with the occurrence of arterial atherosclerotic plaques in NAFLD patients.Conclusion:Serum FGF21 levels are associated with the occurrence of carotid atherosclerotic plaques in patients with NAFLD.

关 键 词：成纤维细胞生长因子21 非酒精性脂肪肝 动脉粥样硬化斑块 

分 类 号：R575.5[医药卫生—消化系统]