溶质载体家族成员7A11与肿瘤免疫调节和耐药关系的研究进展  

Research Progress on the Relationship between Solute Carrier Family Member 7A11 and Tumor Immune Regulation and Drug Resistance

作　　者：杨思琦(综述) 王卫星(审校)[1] YANG Si-qi;WANG Wei-xing(Renmin Hospital of Wuhan University,Wuhan 430060,China)

机构地区：[1]武汉大学人民医院,武汉430060

出　　处：《微循环学杂志》2024年第1期103-108,共6页Chinese Journal of Microcirculation

摘　　要：溶质载体家族成员7A11(SLC7A11)是位于细胞质膜上的胱氨酸转运体,其主要功能是调节谷胱甘肽(GSH)合成、氧化还原维持以及肿瘤的生长和转移等,在多种类型的实体瘤中显著高表达,并参与细胞的铁死亡和双硫死亡过程。SLC7A11对肿瘤的发生发展、免疫调节以及对药物反应的调控等方面均具有重要影响,并为当前大部分肿瘤临床治疗方案的改进提供了依据。Solute carrier family 7 member 11(SLC7A11)is a cysteine transporter located on the cytoplasmic membrane.Its main function is to regulate glutathione(GSH)synthesis,redox maintenance,and tumor growth and metastasis.It is significantly overexpressed in various types of solid tumors and participates in cell ferroptosis and disulfidptosis processes.SLC7A11 has an important impact on the occurrence and development of tumors,immune regulation,and regulation of drug reactions,and provides a basis for improving most current clinical treatment plans for tumors.

关 键 词：SLC7A11 肿瘤免疫 细胞骨架 代谢机制 转运体 胱氨酸代谢 

分 类 号：R73[医药卫生—肿瘤]