肾源性系统性纤维化疾病的化学机制和双鳌合剂法的抑制研究  

Chemical Mechanism of Nephrogenic Systemic Fibrosis and Its Inhibition with Double Chelation

作　　者：詹心琪 周朝晖[2,3] Xinqi Zhan;Zhaohui Zhou(Medical College,Xiamen University,Xiamen 361005,Fujian Province,China;State Key Laboratory of Physical Chemistry of Solid Surfaces,Xiamen 361005,Fujian Province,China;College of Chemistry and Chemical Engineering,Xiamen University,Xiamen 361005,Fujian Province,China)

机构地区：[1]厦门大学医学院,福建厦门361005 [2]固体表面物理化学国家重点实验室,福建厦门361005 [3]厦门大学化学化工学院,福建厦门361005

出　　处：《大学化学》2023年第12期86-90,共5页University Chemistry

基　　金：国家自然科学基金(22179110)。

摘　　要：少数肾病患者使用核磁共振钆造影剂导致肾源性系统性纤维化(NSF)。本文在介绍钆造影剂的基础上,阐述了NSF在生物体内的转化与沉积的机理,揭示了肾源性系统纤维化沉积物的磷酸钆生物微粒形成的化学本质。这有助于进一步了解肾源性系统纤维化的发生、发展和形成机制。并提出在钆造影剂体系中引入具有生物兼容性的第二螯合剂的新思路,以提高造影剂使用的安全性。A small proportion of nephropathy patients administered gadolinium contrast agents for nuclear magnetic resonance have been reported to develop nephrogenic systemic fibrosis(NSF).This paper introduces the mechanism of the transformation and deposition of NSF,aiming to reveal the chemical nature of the gadolinium phosphate bioparticles in nephrogenic system fibrosis.This research will provide an important theoretical basis for future studies on the occurrence,development,and formation of nephrogenic system fibrosis and the removal of sediment residues.Moreover,a new idea for introducing a biocompatible second chelating agent into the gadolinium contrast agent system has been proposed,which aims to improve the safe use of gadolinium contrast agent.

关 键 词：肾源性系统性纤维化 钆造影剂 螯合剂 化学机制 

分 类 号：G64[文化科学—高等教育学] O6[文化科学—教育学]