乳腺癌细胞能量代谢特点  

Characteristics of energy metabolism of breast cancer cells

作　　者：于蕾 王亚奇 梁俊青 崔宏伟 Yu Lei;Wang Yaqi;Liang Junqing;Cui Hongwei(Pharmacy Department of Inner Mongolia Traditional Chinese Medicine Hospital,Hohhot 010020,China;Research Department of Peking University Cancer Hospital(Inner Mongolia Campus)/Affiliated Cancer Hospital of Inner Mongolia Medical University,Hohhot 010020,China;Breast Center of Peking University Cancer Hospital(Inner Mongolia Campus)/Affiliated Cancer Hospital of Inner Mongolia Medical University,Hohhot 010020,China)

机构地区：[1]内蒙古自治区中医医院药剂科,呼和浩特010020 [2]北京大学肿瘤医院内蒙古医院(内蒙古医科大学附属肿瘤医院)科研部,呼和浩特010020 [3]北京大学肿瘤医院内蒙古医院(内蒙古医科大学附属肿瘤医院)乳腺中心,呼和浩特010020

出　　处：《中国组织化学与细胞化学杂志》2023年第5期520-525,共6页Chinese Journal of Histochemistry and Cytochemistry

基　　金：内蒙古自治区“草原英才”工程青年创新创业人才项目;内蒙古自治区“十四五”社会公益领域重点研发和成果转化计划项目(2022YFSH0013);内蒙古科技厅技术攻关项目(2021GG0169);内蒙古自治区公立医院高水平临床专科发展科技项目(2023GLLH0112)。

摘　　要：乳腺癌是严重威胁女性健康的最常见的恶性肿瘤之一。在乳腺癌的恶性转化过程中,癌细胞能量代谢变化是癌细胞的主要特征并促进癌细胞增殖。乳腺癌细胞通过增加葡萄糖代谢产生能量。近年来,人们对代谢改变的复杂机制进行了深入研究,参与这些过程的基因被用作乳腺癌的临床治疗靶点。本文总结近年来与乳腺癌细胞异常代谢特征、调节机制、它们之间的联系以及相关治疗策略相关的最新发现,以期为乳腺癌的预防、诊断、及治疗提供新的思路。Breast cancer is one of the most common malignancies that severely threaten women’s health.During the malignant transformation of breast cancer,changes in cancer cell energy metabolism are a major characteristic and promote cancer cell proliferation.Breast cancer cells generate energy by increasing glucose metabolism.In recent years,there has been an in-depth study of the complex mechanisms of metabolic changes,and genes involved in these processes have been used as clinical treatment targets for breast cancer.This article reviews the latest findings related to the abnormal metabolic characteristics of breast cancer cells,their regulatory mechanisms,the connections between them,and related treatment strategies,in the hope of providing new insights for the prevention,diagnosis,and treatment of breast cancer.

关 键 词：乳腺癌 细胞能量代谢 细胞增殖 葡萄糖代谢 

分 类 号：R737.9[医药卫生—肿瘤]