2-氨基-4-乙酰基嘧啶的合成研究  

Study on Synthesis of 2-Amino-4-Acetylpyrimidine

作　　者：刘杨 包安丽 黄爱玲 张兴 LIU Yang;BAO Anli;HUANG Ailing;ZHANG Xing(Sichuan vocational college of chemical technology,Luzhou 646300,Sichuan,China;Chengdu sino-strong pharmaceutical Co.,Ltd.,Chengdu 611137,Sichuan,China)

机构地区：[1]四川化工职业技术学院,四川泸州646300 [2]成都新恒创药业有限公司,四川成都611137

出　　处：《四川化工》2024年第1期13-15,44,共4页Sichuan Chemical Industry

摘　　要：2-氨基-4-乙酰基嘧啶是乙酰基嘧啶类具有较好生物活性的一种杂环化合物,是制备含嘧啶环的磺胺类药物和磺酰脲类除草剂的重要中间体。研究了2-氨基-4-乙酰基嘧啶的合成途径和合成方法,阐述了用2,3-丁二酮合成2-氨基-4-乙酰基嘧啶的操作步骤和过程,对过程中遇到的问题及解决方法进行了说明,并通过新路径下的操作过程优化确定了最优反应参数和最终路线,为2,3-丁二酮合成2-氨基-4-乙酰基嘧啶探索出了一条安全、高效、高产的合成途径。2-amino-4-acetylpyrimidine is a heterocyclic compound of acetylpyrimidines with good biological activity.It is an important intermediate in the preparation of sulfonamide drugs containing pyrimidine rings and sulfonylurea herbicides.Studied the synthesis pathway and method of 2-amino-4-acetylpyrimidine,elaborated on the operational steps and process of synthesizing 2-amino-4-acetylpyrimidine from 2,3-butanedione,explained the problems encountered during the process and their solutions,and determined the optimal reaction parameters and final route through the optimization of the operating process under the new path.Explored a safe,efficient,and high-yield synthesis pathway for the synthesis of 2-amino-4-acetylpyrimidine from 2,3-butanedione.

关 键 词：2-氨基-4-乙酰基嘧啶 合成路线 3 3-二乙氧基-2-丁酮 烯胺酮 2-氨基-4-(1 1-二乙氧基乙基)嘧啶 最优反应参数 

分 类 号：TQ254.1[化学工程—有机化工]