胃癌合并Hp感染患者胃癌组织中Cyclin D1、VEGF、p27表达及其与临床特征的关系  

Expressions of Cyclin D1,VEGF and p27 in gastric cancer tissues of gastric cancer patients complicated with Hp infection and association with clinical characteristics

作　　者：李先莉 魏忠华[1] 蒋能刚[2] LI Xian-li;WEI Zhong-hua;JIANG Neng-gang(Sichuan Dazhou Central Hospital,Dazhou,Sichuan 635000,China;不详)

机构地区：[1]四川省达州市中心医院医学检验科,四川达州635000 [2]四川大学华西医院实验医学科,四川成都610000

出　　处：《中华医院感染学杂志》2024年第2期196-199,共4页Chinese Journal of Nosocomiology

基　　金：“十三五”国家重点研发计划项目(2019YFF0216501-C20)。

摘　　要：目的研究细胞周期蛋白D1(Cyclin D1)、血管内皮生长因子(VEGF)、p27胃癌组织表达水平与胃癌患者合并幽门螺杆菌(Hp)感染的关系。方法选取2021年1月—2023年2月四川省达州市中心医院收治的胃癌合并Hp感染患者80例及单纯胃癌患者84例分别作为Hp感染组和单纯胃癌组,检测胃癌组织Cyclin D1、VEGF、p27阳性表达情况及其与胃癌合并Hp感染患者临床特征的关系。结果Hp感染组Cyclin D1、VEGF表达阳性率高于单纯胃癌组,p27表达阳性率低于单纯胃癌组(P<0.05);Spearman相关分析显示,胃癌合并Hp感染患者胃癌组织Cyclin D1、VEGF阳性表达与临床分期、分化程度呈正相关(P<0.05),且VEGF阳性表达与淋巴结转移呈正相关关系(P<0.05);p27阳性表达与临床分期、淋巴结转移呈负相关关系(P<0.05)。结论胃癌合并Hp感染患者胃癌组织Cyclin D1和VEGF阳性表达率升高,且阳性表达与患者临床病理特征密切相关。OBJECTIVE To observe the expression levels of cyclin D1(Cyclin D1),vascular endothelial growth fac-tor(VEGF)and p27 in gastric cancer tissues and analyze the association with Helicobacter pylori infection in the gastric cancer patients.METHODS Totally 80 gastric cancer patients complicated with Hp infection and 84 pa-tients with simple gastric cancer who were treated in Sichuan Dazhou Central Hospital from Jan 2021 to Feb 2023 were enrolled in the study and were respectively assigned as the Hp infection group and the simple gastric cancer group.The positive rates of expressions of Cyclin D1,VEGF and p27 in gastric cancer tissues were detected,and the association with the clinical characteristics of the gastric cancer patients complicated with Hp infection was ob-served.RESULTS The positive rates of expressions of Cyclin D1 and VEGF of the Hp infection group were higher than those of the simple gastric cancer group,while the positive rate of expression of p27 of the Hp infection group was lower than that of the simple gastric cancer group(P<0.05).Spearman correlation analysis showed that the positive expressions of Cyclin D1 and VEGF in gastric cancer tissues were positively correlated with clini-cal stage and differentiation degree(P<0.05),the positive expression of VEGF was positively correlated with lymphatic metastasis(P<0.05),while the positive expression of p27 was negatively correlated with clinical stage and lymphatic metastasis(P<0.05).CONCLUSION The positive rates of expressions of Cyclin D1 and VEGF are increased in the gastric cancer tissues of the gastric cancer patients complicated with Hp infection,and the positive expressions are closely associated with the clinicopathologic features.

关 键 词：胃癌 幽门螺杆菌 细胞周期蛋白D1 血管内皮生长因子 P27 临床特征 

分 类 号：R735.2[医药卫生—肿瘤]