化痰醒神汤联合针刺辅助治疗急性期高血压性脑出血临床研究  

Clinical Study on Huatan Xingshen Decoction Combined with Acupuncture for Acute Hypertensive Cerebral Hemorrhage

作　　者：叶红 周倩云 程时杰 周洪武 潘雨洒 YE Hong;ZHOU Qianyun;CHENG Shijie;ZHOU Hongwu;PAN Yusa(Department of Emergency,Xiangshan Hospital of Traditional Chinese Medicine Medical and Health Group,Ningbo Zhejiang 315700,China;Department of Neurology,Xiangshan Hospital of Traditional Chinese Medicine Medical and Health Group,Ningbo Zhejiang 315700,China)

机构地区：[1]象山县中医医院医疗健康集团急诊科,浙江象山315700 [2]象山县中医医院医疗健康集团神经内科,浙江象山315700

出　　处：《新中医》2024年第1期41-45,共5页New Chinese Medicine

摘　　要：目的:观察化痰醒神汤联合针刺辅助治疗急性期高血压性脑出血(HCH)的临床疗效。方法:选取92例急性期HCH患者,采用随机数字表法分为观察组和对照组各46例。对照组予以急诊微创血肿清除手术、常规降颅压、降血压和针刺治疗,观察组在对照组基础上予以化痰醒神汤治疗,均治疗2周。评价2组临床疗效,比较2组治疗前后中医证候积分、美国国立卫生院卒中量表(NIHSS)评分、改良Rankin量表(mRS)评分、平均血流速度(Vm)、搏动指数(PI)、阻力指数(RI)及血清神经生长因子(NGF)、内皮素-1(ET-1)、血管内皮生长因子(VEGF)水平,并统计2组不良反应发生率。结果:观察组总有效率为89.13%,高于对照组71.74%(P<0.05)。治疗后,2组中医证候积分、NIHSS评分及mRS评分均较治疗前降低(P<0.05);且观察组中医证候积分、NIHSS评分及mRS评分均低于对照组(P<0.05)。治疗后,2组Vm、PI高于治疗前,RI低于治疗前(P<0.05);且观察组Vm、PI高于对照组,RI低于对照组(P<0.05)。治疗后,2组NGF高于治疗前,ET-1及VEGF低于治疗前(P<0.05);且观察组NGF高于对照组,ET-1及VEGF低于对照组(P<0.05)。2组不良反应发生率比较,差异无统计学意义(P>0.05)。结论:化痰醒神汤联合针刺辅助治疗急性期HCH风痰阻络证患者疗效确切,可促进神经功能恢复,改善脑血流动力学参数。Objective:To observe the clinical effect of the therapy of Huatan Xingshen Decoction combined with acupuncture on acute hypertensive cerebral hemorrhage(HCH).Methods:A total of 92 patients with acute HCH were selected and divided into the observation group and the control group according to the random number table method,with 46 cases in each group.The control group was treated with minimally invasive hematoma clearance in Department of Emergency,routine intracranial decompression,blood pressure lowering and acupuncture,and the observation group was additionally given Huatan Xingshen Decoction based on the treatment of the control group.The two groups were treated for two weeks.The clinical effects in both groups were evaluated;the traditional Chinese medicine(TCM)syndrome scores,scores of National Institutes of Health Stroke Scale(NIHSS)and Modified Rankin Scale(mRS),mean velocity(Vm),pulsitility index(PI),resistance index(RI)and levels of serum nerve growth factor(NGF),endothelin-1(ET-1)and vascular endothelial growth factor(VEGF)were compared treatment before and afterbetween the two groups;the incidence of adverse reactions in both groups was respectively counted.Results:The total effective rate was 89.13%in the observation group,higher than that of 71.74%in the control group(P<0.05).After treatment,the TCM syndrome scores,and scores of NIHSS and mRS in both groups were decreased when compared with those before treatment(P<0.05);the above scores in the observation group were lower than those in the control group(P<0.05).After treatment,the Vm and PI in both groups were higher than those before treatment,and the RI was lower than that before treatment(P<0.05);the Vm and PI in the observation group were higher than those in the control group,and the RI was lower than that in the control group(P<0.05).After treatment,the NGF levels in both groups were higher than those before treatment,and the levels of ET-1 and VEGF were lower than those before treatment(P<0.05);the NGF level in the observation group was higher

关 键 词：急性期高血压性脑出血 化痰醒神汤 针刺 脑血流动力学参数 神经功能 日常生活功能 

分 类 号：R743.2[医药卫生—神经病学与精神病学]