凉血散瘀汤联合胰激肽原酶治疗糖尿病视网膜病变临床研究  

Clinical Study on Liangxue Sanyu Decoction Combined with Pancreatic Kallikrein for Diabetic Retinopathy

作　　者：宋艳 王世娟 王予 杨丽[1] 董昆仑 陈文生 SONG Yan;WANG Shijuan;WANG Yu;YANG Li;DONG Kunlun;CHEN Wensheng(Department of Ophthalmology,Nanyang Second General Hospital,Nanyang Henan 473000,China)

机构地区：[1]南阳市第二人民医院眼科,河南南阳473000

出　　处：《新中医》2024年第1期88-93,共6页New Chinese Medicine

基　　金：河南省医学科技公关项目(LHGJ20191477)。

摘　　要：目的:观察凉血散瘀汤联合胰激肽原酶治疗糖尿病视网膜病变的临床疗效。方法:选取糖尿病视网膜病变患者126例,按随机数字表法分为西药组、中药组和联合组,每组42例。西药组给予胰激肽原酶肠溶片口服,中药组给予凉血散瘀汤口服,联合组给予凉血散瘀汤联合胰激肽原酶治疗。3组连续治疗3个月。评价3组治疗前后中医证候评分,检测3组治疗前后眼动脉的收缩期峰值流速(PSV)、舒张末期血流速度(EDV)及血清超敏C-反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-α(TNF-α)水平,检测3组治疗前后视功能。结果:治疗后,3组各项中医证候评分较治疗前降低(P<0.05);且联合组各项中医证候评分低于西药组和中药组(P<0.05)。治疗后,3组PSV、EDV水平较治疗前升高(P<0.05);且联合组PSV、EDV水平高于西药组和中药组(P<0.05)。治疗后,3组hs-CRP、IL-6、TNF-α水平低于治疗前(P<0.05),且联合组hs-CRP、IL-6、TNF-α水平低于西药组和中药组(P<0.05)。治疗后,3组最佳矫正视力、视网膜厚度较治疗前升高,视野灰度值较治疗前降低(P<0.05);联合组最佳矫正视力、视网膜厚度高于西药组和中药组,视野灰度值低于西药组和中药组(P<0.05)。结论:凉血散瘀汤联合胰激肽原酶治疗糖尿病视网膜病变可以改善患者临床症状,降低机体炎症因子水平,改善眼底血流动力学和视功能。Objective:To observe the clinical effect of Liangxue Sanyu Decoction combined with pancreatic kallikrein for diabetic retinopathy.Methods:A total of 126 patients with diabetic retinopathy were selected and divided into the western medicine group,the Chinese medicine group and the combination group according to the random number table method,with 42 cases in each group.The western medicine group was treated with Pancreatic Kininogenase Enteric-Coated Tablets for oral use,the Chinese medicine group was treated with Liangxue Sanyu Decoction for oral use,and the combination group was treated with Liangxue Sanyu Decoction combined with pancreatic kallikrein.The three groups were treated continuously for 3 months.The traditional Chinese medicine(TCM)syndrome scores were evaluated in the three groups before and after treatment.The peak systolic flow velocity(PSV)and end diastolic blood flow velocity(EDV)of the ophthalmic artery,as well as the levels of hypersensitive C-reactive protein(hs-CRP),interleukin-6(IL-6),and tumor necrosis factor-α(TNF-α)were detected before and after treatment.The visual function was detected before and after treatment in three groups.Results:After treatment,the TCM syndrome scores in the three groups were decreased when compared with those before treatment(P<0.05);the TCM syndrome scores in the combination group were lower than those in the western medicine group and the Chinese medicine group(P<0.05).After treatment,the levels of PSV and EDV in the three groups were increased when compared with those before treatment(P<0.05);the levels of PSV and EDV in the combination group were higher than those in the western medicine group and the Chinese medicine group(P<0.05).After treatment,the levels of hs-CRP,IL-6,and TNF-αin the three groups were lower than before treatment(P<0.05),and the levels of hs-CRP,IL-6,and TNF-αin the combination group were lower than those in the western medicine group and the Chinese medicine group(P<0.05).After treatment,the best corrected visual acuity and retinal

关 键 词：糖尿病视网膜病变 凉血散瘀汤 胰激肽原酶 炎症因子 视功能 

分 类 号：R774.1[医药卫生—眼科]