低浓度开塞露灌肠对降低早产儿发生坏死性小肠结肠炎危险因素的效果评价  

Evaluation of the Effect of Low Concentration Enema with Glycerol Enema on Reducing Risk Factors for Necrotizing Enterocolitis in Premature Infants

作　　者：卢艳华 钟小丽 曾冰英 朱静露 章丽燕 连少蓉 黄晓 肖清芳 LU Yanhua;ZHONG Xiaoli;ZENG Bingying;ZHU Jinglu;ZHANG Liyan;LIAN Shaorong;HUANG Xiao;XIAO Qingfang(Department of Neonatology,Fuzhou Children's Hospital,Fuzhou 350001,China)

机构地区：[1]福建省福州儿童医院新生儿科,福州350001

出　　处：《中国医药指南》2024年第6期37-39,共3页Guide of China Medicine

基　　金：福州市卫生健康中青年科学研究项目,项目编号:2020-S-wq23。

摘　　要：目的探讨低浓度开塞露灌肠对降低早产儿发生坏死性小肠结肠炎危险因素的效果。方法将2020年10月至2023年10月40例胎龄为24~32周,出生体重为500~1500 g的早产儿随机分为两组,一组20例使用浓度为50%的开塞露(GE)每8 h一次灌肠,另一组20例使用浓度为25%的开塞露灌肠,比较两组患儿不耐受及新生儿坏死性小肠结肠炎(NEC)发生率、胎儿胎粪排净、恢复正常体重及达全肠道喂养及住院时间。结果25%GE组喂养不耐受发生率为60%,50%GE组发生率为75%,25%GE组较50%GE低,但无统计学意义(P>0.05),在NEC发生率上,两组均发生3例,发生率均为15%,无统计学差异(P>0.05)。结论使用25%浓度的开塞露为早产儿灌肠可减少喂养不耐受,使患儿更快到达全肠内营养,减少肠外营养(TPN)使用,且安全性好。Objective To explore the effect of low concentration enema with glycerol enema on reducing the risk factors of necrotizing enterocolitis in premature infants.Methods From October 2020 to October 2023,40 premature infants with gestational age ranging from 24 weeks to 32 weeks and birth weight ranging from 500-1500g were randomly divided into two groups.One group consisted of 20 case who received every 8 hours enema with 50%concentration of enema(GE),while the other group consisted of 20 case who received enema with 25%concentration of enema.The incidence of intolerance and neonatal necrotizing enterocolitis(NEC),fetal meconium clearance,normal weight,full intestinal feeding and length of hospital stay were compared between the two groups.Results The incidence of feeding intolerance in the 25%GE group was 60%,while the incidence in the 50%GE group was 75%.The incidence in the 25%GE group was lower than that in the 50%GE group,but there was no statistically significant difference(P>0.05).In terms of NEC incidence,both groups had 3 cases,and the incidence rate was 15%,with no statistically significant difference(P>0.05).Conclusions The use of 25%concentration of enema with glycerol enema for premature infants can reduce feeding intolerance,enable children to reach full enteral nutrition faster,reduce the use of parenteral nutrition(TPN),and have good safety.

关 键 词：开塞露 早产儿 坏死性小肠结肠炎 

分 类 号：R574.62[医药卫生—消化系统] R722[医药卫生—内科学]