暖水燥土方治疗阳虚化风型帕金森病非运动症状的临床研究  

Clinical study on the treatmtnt of non-motor symptoms of Parkinson's disease with yang deficiency causing wind by Nuan Shui Zao Tu formula

作　　者：马倩文 金杰[1] 秦润笋[1] 刘洁[1] 钱百成[1] 胡勋 沈晓明 MA Qianwen;JIN Jie;QIN Runsun;LIU Jie;QIAN Baicheng;HU Xun(The first Affiliated Hospital of Henan University of Traditional Chinese Medicine,Zhengzhou 450000,China;Zhoug Mu County Hospital of Traditional Chinese Medicine,Zhengzhou 451470,China)

机构地区：[1]河南中医药大学第一附属医院,郑州450000 [2]中牟县中医院,郑州451470 [3]不详

出　　处：《长春中医药大学学报》2024年第1期60-64,共5页Journal of Changchun University of Chinese Medicine

基　　金：河南省中医药科学研究专项课题(20-21ZY2038);河南省中医学“双一流”创建科学研究专项课题(HSRP-DFCTCM-2023-5-16);2021财政专项-2020年省级卫生健康补助资金-中医药传承与创新人才工程(仲景工程)-金杰(第二批青苗CZ0236-25)。

摘　　要：目的 探讨暖水燥土方治疗帕金森病非运动症状的有效性和安全性,为帕金森病非运动症状患者选择合适的治疗方法提供临床数据支持。方法 将60例受试者随机分为治疗组和对照组,治疗前后的相关评定量表,具体有帕金森病评定量表Ⅲ(UPDRS Ⅲ)、Hoehn-Yahr(H-Y)分期、非运动症状筛查量表(NMSS)、帕金森病生活质量问卷-39(PDQ-39)。结果 治疗组和对照组治疗后UPDRSⅢ评分均明显下降(P <0.01),治疗组治疗后NMSS、PDQ-39评分明显下降(P <0.01),对照组治疗前后无统计学意义(P> 0.05),2组H-Y、UPDRS Ⅲ评分差异无统计学意义(P> 0.05),治疗组NMSS各症状评分睡眠疲劳、胃肠道功能、泌尿系统评分均明显下降(P <0.05),NMSS、PDQ-39有效率分别为63.3%、53.5%,疗效均高于对照组。结论 治疗组能有效改善帕金森病非运动症状,提高患者的生活质量,改善睡眠质量、胃肠道功能及泌尿情况。治疗组和对照组均能改善帕金森病患者病情程度,在改善运动症状方面,治疗组无明显优势。Objective To explore the eficacy and safety of the Nuan Shui Zao Tu formula in the treatment of non-motor symptoms of Parkinson's disease,in order to provide authentic data reference for the application of appropriate treatment plans for patients with non-motor symptoms of Parkinson's disease.Methods 60 subjects were randomly divided into the treatment group and the control group.The scores of Unified Parkinson's Disease Rating Scale II(UPDRS II),Hoehn-Yahr(H-Y)staging,Non Motor Symptom Screening Scale(NMSS),and Parkinson's Disease Quality of Life Questionnaire-39(PDQ-39)were observed in both groups.Results UPDRS III scores decreased significantly in both groups after treatment(P<0.01).After treatment,NMSS and PDQ-39 scores decreased significantly in the treatment group(P<0.01),and there was no statistically significant difference in NMSS and PDQ-39 scores before and after treatment in the control group(P>0.05).There was no statistically significant difference in H-Y and UPDRS II scores between two groups(P>0.05).The symptom scores of NMSS in the treatment group,including sleep fatigue,gastrointestinal function,and urinary system scores,were significantly decreased(P<0.05).The effective rates of the NMSS and PDQ-39 in the treatment group were 63.3%and 53.5%,respectively.And therapeutic effect in the treatment group was higher than that of the the control group.Conclution The treatment group can effectively improve the non-motor symptoms of Parkinson's disease,enhance the quality of life of the patients,and improve sleep quality,gastrointestinal function and urinary condition of the patients.The treatment group and the control group can improve the degree of the patients with Parkinson's disease,and there is no significant advantage in improving motor symptoms in the treatment group.

关 键 词：暖水燥土方 帕金森病 非运动症状 临床研究 

分 类 号：R742.5[医药卫生—神经病学与精神病学]