Unveiling DNA methylation in Alzheimer’s disease:a review of array-based human brain studies  

作　　者：Victoria Cunha Alves Eva Carro Joana Figueiro-Silva 

机构地区：[1]Neurodegenerative Diseases Group,Hospital Universitario 12 de Octubre Research Institute(imas12),Madrid,Spain [2]Network Center for Biomedical Research,Neurodegenerative Diseases(CIBERNED),Madrid,Spain [3]PhD Program in Neuroscience,Autonoma de Madrid University,Madrid,Spain [4]Neurotraumatology and Subarachnoid Hemorrhage Group,Hospital Universitario 12 de Octubre Research Institute(imas12),Madrid,Spain [5]Neurobiology of Alzheimer’s Disease Unit,Functional Unit for Research Into Chronic Diseases,Instituto de Salud Carlos III,Madrid,Spain [6]Institute of Medical Genetics,University of Zurich,Zurich,Switzerland [7]Department of Molecular Life Science,University of Zurich,Zurich,Switzerland

出　　处：《Neural Regeneration Research》2024年第11期2365-2376,共12页中国神经再生研究（英文版）

摘　　要：The intricacies of Alzheimer’s disease pathogenesis are being increasingly illuminated by the exploration of epigenetic mechanisms,particularly DNA methylation.This review comprehensively surveys recent human-centered studies that investigate whole genome DNA methylation in Alzheimer’s disease neuropathology.The examination of various brain regions reveals distinctive DNA methylation patterns that associate with the Braak stage and Alzheimer’s disease progression.The entorhinal cortex emerges as a focal point due to its early histological alterations and subsequent impact on downstream regions like the hippocampus.Notably,ANK1 hypermethylation,a protein implicated in neurofibrillary tangle formation,was recurrently identified in the entorhinal cortex.Further,the middle temporal gyrus and prefrontal cortex were shown to exhibit significant hypermethylation of genes like HOXA3,RHBDF2,and MCF2L,potentially influencing neuroinflammatory processes.The complex role of BIN1 in late-onset Alzheimer’s disease is underscored by its association with altered methylation patterns.Despite the disparities across studies,these findings highlight the intricate interplay between epigenetic modifications and Alzheimer’s disease pathology.Future research efforts should address methodological variations,incorporate diverse cohorts,and consider environmental factors to unravel the nuanced epigenetic landscape underlying Alzheimer’s disease progression.

关 键 词：Alzheimer’s disease ANK1 BIN1 DNA methylation epigenome-wide association studies HOXA3 MCF2L RHBDF2 

分 类 号：R749.16[医药卫生—神经病学与精神病学]