Mechanism of Cu entry into the brain:many unanswered questions  

作　　者：Shubhrajit Roy Svetlana Lutsenko 

机构地区：[1]Department of Physiology,Johns Hopkins University School of Medicine,Baltimore,MD,USA

出　　处：《Neural Regeneration Research》2024年第11期2421-2429,共9页中国神经再生研究（英文版）

基　　金：supported by the National Institute of Health grant R01 GM101502(to SL).

摘　　要：Brain tissue requires high amounts of copper(Cu)for its key physiological processes,such as energy production,neurotransmitter synthesis,maturation of neuropeptides,myelination,synaptic plasticity,and radical scavenging.The requirements for Cu in the brain vary depending on specific brain regions,cell types,organism age,and nutritional status.Cu imbalances cause or contribute to several life-threatening neurologic disorders including Menkes disease,Wilson disease,Alzheimer’s disease,Parkinson’s disease,and others.Despite the well-established role of Cu homeostasis in brain development and function,the mechanisms that govern Cu delivery to the brain are not well defined.This review summarizes available information on Cu transfer through the brain barriers and discusses issues that require further research.

关 键 词：ATOX1 ATP7A ATP7B blood-brain barrier BRAIN choroid plexus COPPER SLC31A1 

分 类 号：R338[医药卫生—人体生理学]