二甲双胍调节MEK/ERK通路及基质金属蛋白酶在恶性肿瘤中应用的研究进展  

Research Progress of Application of Metformin Regulating MEK/ERK Pathway and Matrix Metalloproteinases in Malignant Tumors

作　　者：马君昳 王琦 张凯 王大丰 左燕雨 裴书飞 赵先群[6] 张晓亚[7] 耿云平[7] 李治岐 万里新[2] MA Junyi;WANG Qi;ZHANG Kai;WANG Dafeng;ZUO Yanyu;PEI Shufei;ZHAO Xianqun;ZHANG Xiaoya;GENG Yunping;LI Zhiqi;WAN Lixina(Clinical Medical College of Henan University,Kaifeng 475000,China;Department of Oncology,Nanyang Central Hospital,Nanyang 473000,China;Department of Radiotheray,Nanyang Central Hospital,Nanyang 473000,China;Department of Pharmacy,Nanyang Central Hospital,Nanyang 473000,China;Department of Cardiology,Nanyang Central Hospital,Nanyang 473000,China;Department of Gastrology,Nanyang Central Hospital,Nanyang 473000,China;Department of Imaging,Nanyang Central Hospital,Nanyang 473000,China)

机构地区：[1]河南大学临床医学院,河南开封475000 [2]南阳市中心医院肿瘤内科,河南南阳473000 [3]南阳市中心医院放疗科,河南南阳473000 [4]南阳市中心医院药学部,河南南阳473000 [5]南阳市中心医院心血管内科,河南南阳473000 [6]南阳市中心医院消化内科,河南南阳473000 [7]南阳市中心医院影像科,河南南阳473000

出　　处：《医学综述》2024年第4期444-451,共8页Medical Recapitulate

基　　金：河南省医学科技攻关计划联合共建项目(LHGJ20210978)。

摘　　要：二甲双胍是目前治疗2型糖尿病的一线用药,其通过改善胰岛素抵抗、抑制肝脏糖异生等途径降低血糖。近年发现,二甲双胍还可通过促分裂原活化的蛋白激酶激酶/胞外信号调节激酶信号通路以及基质金属蛋白酶诱导细胞周期停滞、促进细胞凋亡、抑制细胞侵袭迁移,并可与各种抗肿瘤药物联用发挥协同作用以抑制肿瘤进展。但目前仍缺乏二甲双胍可以抑制癌症患者病情进展的研究证据,未来还需要对二甲双胍在恶性肿瘤治疗中的作用及其有效性、安全性进行进一步研究。Metformin is the current first-line drug for type 2 diabetes mellitus,which reduces blood sugar by improving insulin resistance and inhibiting liver gluconeogenesis.In recent years,it has been found that metformin can also induce cell cycle arrest,promote apoptosis,inhibit invasion and migration through mitogen-activated protein kinase kinase/extracellular signal-regulated kinase signaling pathway and matrix metalloproteinases,and can play a synergistic role in inhibiting tumor progression when combined with various anti-tumor drugs.However,there is still a lack of research evidence that metformin can inhibit the progression of cancer patients,and further research is needed on the role,effectiveness,and safety of metformin in the treatment of malignant tumors in the future.

关 键 词：恶性肿瘤 二甲双胍 促分裂原活化的蛋白激酶激酶/胞外信号调节激酶信号通路 基质金属蛋白酶 

分 类 号：R730.5[医药卫生—肿瘤]