我国婴幼儿人群膳食亚硝酸盐暴露风险评估  

Dietary nitrite exposure risk assessment in Chinese children between 3 months and 3 years old

作　　者：马凯杰 宋雁 周颖颖 雍凌 宁钧宇[1,2] MA Kai-Jie;SONG Yan;ZHOU Ying-ying;YONG Ling;NING Jun-yu(School of Public Health,Capital Medical University,Beijing 100069,China;Beijing Center for Disease Prevention and Control,Beijing Key Laboratory of Diagnostic and Traceability Technologies for Food Poisoning,Beijing 100013,China;China National Center for Food Safety Risk Assessment,Beijing 100022,China)

机构地区：[1]首都医科大学公共卫生学院,北京100069 [2]北京市疾病预防控制中心,食物中毒诊断溯源技术北京市重点实验室,北京100013 [3]国家食品安全风险评估中心,北京100022

出　　处：《毒理学杂志》2023年第6期455-461,共7页Journal of Toxicology

基　　金：中国食品科学技术学会食品科技基金重点研发计划;北京市高层次公共卫生技术人才建设项目学科带头人。

摘　　要：目的评价我国南北方地区、多省份婴幼儿人群亚硝酸盐膳食暴露水平及潜在的健康风险。方法通过概率评估法将我国18384名3~35月龄婴幼儿日常生活中食品消费数据与61609份食品中亚硝酸盐含量数据的相结合,以0.07 mg/kg·bw为每日允许摄入量(acceptable daily intake ADI),对我国3月龄以上、3岁以下婴幼儿膳食中亚硝酸盐暴露风险进行评估。结果亚硝酸盐含量较高的食品是肉类制品和水产制品,其中又以肉罐头、酱卤肉和肉灌肠类食品尤为突出。婴幼儿人群亚硝酸盐平均暴露量为3.07μg/kg·bw,其中南、北方地区婴幼儿膳食亚硝酸盐平均暴露量分别为3.37和2.81μg/kg·bw。我国婴幼儿膳食亚硝酸盐的主要来源是肉类制品,其次是新鲜蔬菜、婴幼儿配方食品、水产制品和婴幼儿辅助食品,这五类食品的总贡献率超过90%。结论婴幼儿人群亚硝酸盐暴露水平不存在性别差异,婴幼儿自各类食品中摄入的亚硝酸盐远远低于健康指导值,表明我国婴幼儿人群亚硝酸盐膳食暴露风险较低。Objective To evaluate the dietary exposure level of nitrite and its potential health risks in infants and young children in southern and northern regions and different provinces.Methods Food consumption data of 18384 Chinese infants from 3 to 35 months and 61609 food nitrite concentration data were used to calculate the nitrate exposure by probability assessment method.The acceptable daily intake for children between 3 to 35 months old was 0.07 mg/kg·bw.Results The foods with high content of nitrite were meat products and aquatic products,among which canned meat,cured meat and sausages were those of highest contents.The average exposure of infants to nitrite was 3.07μg/kg·bw,and the average dietary nitrite exposure of infants in the southern and northern regions were 3.37 and 2.81μg/kg·bw,respectively.The main sources of dietary nitrite in infants and young children of China were meat products,followed by fresh vegetables,infant formula foods,aquatic products,infant complementary foods,the total contribution of the five foods is more than 90%.Conclusion There is no gender difference in the exposure level of nitrite,and the intake of nitrite from various foods of infants and young children is well below the acceptable daily intake,indicating that the dietary exposure risk of nitrite is low in Chinese infants and young children.

关 键 词：亚硝酸盐 暴露评估 膳食摄入量 婴幼儿 概率评估 

分 类 号：R99[医药卫生—毒理学] R114[医药卫生—药学]