Discovery of Novel Anthranilic Diamide Derivatives Bearing Sulfoximine Group as Potent Insecticide Candidates  

作　　者：ZHANG Hongyuan PENG Jinmin ZHONG Yuanhan CHEN Yue WANG Qing Haditullah HADIATULLAH XIE Weibin XIONG Lixia YUCHI Zhiguang LIU Jingbo LI Yuxin 

机构地区：[1]State Key Laboratory of Elemento-Organic Chemistry,College of Chemistry,Nankai University,Tianjin,300071,P.R.China [2]Nankai University&Cangzhou Bohai New Area Institute of Green Chemical Engineering,Changzhou,062550,P.R.China [3]College of Horticulture and Landscape Architecture,Tianjin Agricultural University,Tianjin,300392,P.R.China [4]Tianjin Key Laboratory for Modern Drug Delivery and High-efficiency,Collaborative Innovation Center of Chemical Science and Engineering,School of Pharmaceutical Science and Technology,Tianjin University,Tianjin,300072,P.R.China

出　　处：《Chemical Research in Chinese Universities》2024年第1期96-108,共13页高等学校化学研究（英文版）

基　　金：Nankai University Cangzhou Bohai New Area Green Chemical Research Institute(NCC)Fund,the National Natural Science Foundation of China(Nos.31972287,32022073);the National Key Research and Development Program of China(No.2022YFE0108400);the Scientific Project of Tianjin Municipal Education Commission,China(No.2022KJ026).

摘　　要：The fall armyworm,Spodoptera frugiperda(S.frugiperda),represents the most resistant insect species and poses serious threat to grain yield.Chlorantraniliprole(CHL),which targets the ryanodine receptors(RyRs)in insects,has demonstrated the efficacy in controlling S.frugiperda.Nevertheless,this has led to emerging resistance in several countries.To counter this resistance,a viable approach involves the development of novel compounds that bind against RyRs via distinct binding sites or modes.In this study,a series of 22 novel anthranilic diamide derivatives was designed and synthesized,and their insecticidal activities were evaluated.Most of these derivatives showed moderate to good insecticidal activity against S.frugiperda and Mythimna separata.Time-lapse fluorescence measurements of endoplasmic reticulum luminal calcium revealed that most derivatives elicited cellular responses similar as CHL when assessed on HEK293 cells expressing S.frugiperda ryanodine receptors(SfRyRs).The mode of action of compound 13a was studied and verified on the isolated neurons by calcium imaging technique.Finally,molecular docking analysis was employed to predict the binding mechanism of compound 13a against SfRyRs.Overall,these novel diamide derivatives hold promise as a valuable resource for guiding the future design of insecticidal compounds targeting RyRs.

关 键 词：Anthranilic diamide derivative SULFOXIMINE Spodoptera frugiperda Mode of action Molecular docking 

分 类 号：O62[理学—有机化学]