Strategy for Detecting Systemic Treatment Sensitivity of Primary Liver Cancer Based on a Novel Infrared-emissive Organic Nanoparticle  

作　　者：WU Jun LI Yongzhi QIN Hanjiao GAO Ying YANG Bing SHENG Jiyao ZHANG Xuewen 

机构地区：[1]Department of Hepatobiliary and Pancreatic Surgery,the Second Hospital of Jilin University,Changchun,130022,P.R.China [2]Department of Radiation Oncology,the Second Hospital of Jilin University,Changchun,130022,P.R.China [3]State Key Laboratory of Supramolecular Structure and Materials,Institute of Theoretical Chemistry,College of Chemistry,Jilin University,Changchun,130012,P.R.China

出　　处：《Chemical Research in Chinese Universities》2024年第1期145-152,共8页高等学校化学研究（英文版）

基　　金：the National Natural Science Foundation of China(Nos.82002809,81902484,52103209);the China Postdoctoral Science Foundation(No.2020M670864);the Medical and Health Talents Project of Jilin Province,China(No.2020SCZT097);the Youth Support Project of Jilin Association for Science and Technology,China(No.202028);the Jilin Province Science and Technology Development Plan,China(No.20210204028YY);the Natural Science Foundation of Jilin Province,China(No.YDZJ202301ZYTS080).

摘　　要：In this study,we synthesized an organic material with near-infrared emission capabilities:4-(2-(4-(9-(4-(diphenylamino)phenyl)naphtho[2,3-c][1,2,5]thiadiazol-4-yl)phenyl)-1H-phenol-1-ylidene)malononitrile(TPA).Furthermore,TPA-PEG2000 fluorescent nanoparticles were prepared via coating the shells with PEG2000.TPA-PEG2000 exhibited strong near-infrared emission near 700 nm,with a photoluminescence quantum yield of 15.09%,indicating a high emission efficiency.Molecular biology experiments have confirmed its low toxicity and excellent biocompatibility.Increased cholesterol and phospholipid levels in liver cancer cell membranes with low sensitivity or high drug resistance lead to increased rigidity,reduced membrane fluidity,reduced endocytic efficiency,and reduced uptake.Therefore,the uptake of TPA-PEG2000 nanoparticles into cells and the near-infrared fluorescence intensity can be used to evaluate the sensitivity of systemic liver cancer treatment in a simple and efficient manner.

关 键 词：NANOPARTICLE NEAR-INFRARED FLUORESCENCE Systemic treatment sensitivity Cell membrane fluidity 

分 类 号：R730.5[医药卫生—肿瘤] TB383[医药卫生—临床医学]