奥卡西平对听觉皮质影响的功能磁共振研究  

Functional Magnetic Resonance Imaging Study of Oxcarbazepine Effect on Auditory Cortex

作　　者：李锐[1] 陈蕾[1] 唐钰莎 田肖和 LI Rui;CHEN Lei;TANG Yusha(Department of Neurology,West China Hospital of Sichuan University,Sichuan 610041,China)

机构地区：[1]四川大学华西医院神经内科,成都610041 [2]四川省功能与分子影像重点实验室,成都6100411

出　　处：《医学研究杂志》2023年第12期32-36,共5页Journal of Medical Research

基　　金：国家自然科学基金资助项目(81871018);四川省杰出青年科技基金资助项目(2020JDJQ0018)。

摘　　要：目的利用功能磁共振探索奥卡西平对癫痫患者听觉皮质功能的影响。方法收集21例应用奥卡西平(奥卡西平组)及21例年龄、性别匹配但未使用奥卡西平治疗的癫痫患者(非奥卡西平组)。利用低频振幅(amplitude of low frequency fluctuation,ALFF)和局域一致性(regional homogeneity,ReHo)比较两组患者听觉皮质功能活动差异。结果与非奥卡西平组比较,奥卡西平组在右侧颞上回、双侧颞中回以及视觉联合皮质等区域ALFF值增高,双侧眶额区及颞下回等区域ALFF值降低;在右侧颞上回、双侧颞中回、眶额区及左侧视觉联合皮质等区域ReHo值增高,而在双侧颞上回、颞下回、右侧颞中回等区域ReHo值降低。在同一横断面,右侧颞上回、右侧扣带回、右侧体感皮质及左侧视觉联合皮质区域ALFF及ReHo均增强,双侧颞下回ALFF及ReHo均减弱。但两组在双侧颞横回及颞横沟等区域ALFF和ReHo值的差异无统计学意义。结论奥卡西平可能会影响癫痫患者听觉皮质功能,并且主要作用于次级听觉皮质或调节听觉网络的兴奋性平衡。Objective Functional magnetic resonance imaging was used to explore the effects of oxcarbazepine on auditory cortex function in patients with epilepsy.Methods 21 patients with epilepsy treated with oxcarbazepine and twenty-one patients with epilepsy who matched age and gender but did not treat with oxcarbazepine were collected.Amplitude of low frequency fluctuation(ALFF)and regional homogeneity(ReHo)were used to compare the differences in the functional activity of the auditory cortex between the two groups.Results Compared with the patients without oxcarbazepine,the patients with oxcarbazepine had higher ALFF values in the right superior temporal gyrus,bilateral middle temporal gyrus and visual union cortex,and lower ALFF values in the bilateral orbitofrontal area and inferior temporal gyrus,the patients with oxcarbazepine had higher ReHo values in right superior temporal gyrus,bilateral middle temporal gyrus,orbitofrontal area,and left visual union cortex,and lower ReHo values in bilateral superior temporal gyrus,inferior temporal gyrus and right middle temporal gyrus.In the same cross-sectional area,ALFF and ReHo values were enhanced in the right superior temporal gyrus,right cingulate gyrus,right somatosensory cortex and left visual union cortex,while ALFF and ReHo values were weakened in the bilateral inferior temporal gyrus.However,there was no significant difference in ALFF and ReHo values of bilateral transverse temporal gyrus and transverse temporal sulcus between the two groups.Conclusion Oxcarbazepine may affect auditory cortex function in patients with epilepsy,and it mainly acts on the secondary auditory cortex or regulates the excitatory balance of the auditory network.

关 键 词：癫痫 静息态功能磁共振 奥卡西平 听觉皮质 

分 类 号：R742[医药卫生—神经病学与精神病学] R971[医药卫生—临床医学]