浅表CD34阳性纤维母细胞肿瘤研究进展  

Research progress in Superficial CD34-positive Fibroblastic Tumor

作　　者：刘旭[1] 刘娇 陈路[1] 胡余昌[1] 刘宇飞[1] LIU Xu;LIU Jiao;CHEN Lu;HU Yuchang;Liu Yufei(Institute of Pathology,China Three Gorges University/Department of Pathology,Yichang Central People’s Hospital,Yichang 443001,China;Department of Obstetrics,Affiliated Renhe Hospital of China Three Gorges University,Yichang 443001,China.)

机构地区：[1]三峡大学病理学研究所/宜昌市中心人民医院病理科,湖北宜昌443008 [2]三峡大学附属仁和医院产科,湖北宜昌443001

出　　处：《中国肿瘤外科杂志》2023年第6期621-624,共4页Chinese Journal of Surgical Oncology

摘　　要：浅表CD34阳性纤维母细胞肿瘤(SCPFT/SCD34FT)是近年来新认识的一种罕见的间叶源性肿瘤,主要发生于下肢皮下浅表软组织内,患者常因发现包块数年后渐进增大伴疼痛就诊,临床上无特殊表现及实验室检查指标,确诊依靠病理学。镜下表现为形态相对温和的梭形细胞中混杂大量怪异核的多形性细胞,核仁清晰,核分裂像罕见(≤1个/50HPF),可出现核内假包涵体,部分细胞质丰富颗粒状、玻璃状嗜酸性,未见坏死。免疫组织化学弥漫表达CD34、Vimentin、WT1及CADM3/SynCAM3,Ki-67增值指数<1%。约42%病例存在PRDM10基因重排。该肿瘤整体预后良好,少数病例可出现复发或淋巴结转移,未见死亡病例报道。文章总结和归纳SCPFT的特征,以期为临床诊治提供参考。Superficial CD34-positive fibroblastic tumor(SCPFT/SCD34FT)is a rare mesenchymal tumor newly recognized in recent years,which mainly occurs in the subcutaneous superficial soft tissue of the lower extremities.Patients often see a doctor because of the gradual enlargement of the mass with pain several years later,and there are no special clinical manifestations and laboratory indicators,so the diagnosis depends on pathology.Under the microscope,it can be seen that the relatively mild spindle cells are mixed with strange cells,which are polymorphic,with nucleolus visible but rare mitotic image(≤1/50HPF).Intranuclear pseudoinclusion bodies and eosinophilic granular cytoplasm may appear.There’s no tumor necrosis.Immunohistochemical diffuse expression of CD34,Vimentin,WT1,and CADM3/SynCAM3,Ki-67 index is<1%.PRDM10 gene rearrangement is present in about 42%of cases.The overall prognosis of this tumor is good,recurrence or lymph node metastasis occurred in a few cases,and no deaths have been reported.This article comprehensively reviews all SCPFT reports in domestic and foreign literature,and summarizes them,hoping to provide new understanding and reference for clinicians.

关 键 词：浅表CD34阳性纤维母细胞肿瘤 间叶源性肿瘤 临床及病理 免疫组织化学 PRDM10 

分 类 号：R738.6[医药卫生—肿瘤]