微小RNA在脉络膜新生血管相关信号通路中的研究进展  

Research progress of microRNA in choroidal neovascularization signaling pathway

作　　者：杨凌齐 吕洋 Yang Lingqi;Lyu Yang(First School of Clinical Medical,Gansu University of Chinese Medicine,Lanzhou 730000,Gansu Province,China;Ophthalmic Center,the 940th Hospital of Joint Service Support Forces of the Chinese People's Liberation Army,Lanzhou 730050,Gansu Province,China;Laboratory of Stem Cell and Gene Medicine of Gansu Province,the 940th Hospital of Joint Service Support Forces of the Chinese People's Liberation Army,Lanzhou 730050,Gansu Province,China)

机构地区：[1]甘肃省中医药大学第一临床医学院,中国甘肃省兰州市730000 [2]中国人民解放军联勤保障部队第九四○医院眼科中心,中国甘肃省兰州市730050 [3]中国人民解放军联勤保障部队第九四○医院基础医学实验室、甘肃省干细胞与基因药物重点实验室,中国甘肃省兰州市730050

出　　处：《国际眼科杂志》2024年第3期362-367,共6页International Eye Science

基　　金：国家自然科学基金资助项目(No.82000926);甘肃省卫生健康行业科研项目(No.GSWSKY2022-05);中国人民解放军联勤保障部队第九四○医院院内科研计划项目(No.2023yxky033);甘肃省中医药大学导师专项(No.2023TXKT011)。

摘　　要：脉络膜新生血管(CNV)是多种眼部疾病的最终病理表现,其发病机制极其复杂,涉及多种细胞、细胞因子及信号通路。微小RNA(miRNA)作为一种生物小分子,是由22个核苷酸组成的非编码RNA,可通过降解或抑制靶基因mRNA翻译调节基因表达。随着学者对其研究的深入,miRNA介导的信号通路参与各种疾病发展的机制逐渐被揭示。在眼科领域,miRNA通过各种信号通路靶向特定蛋白基因,从而起到促进或抑制CNV的作用。因此,揭示miRNA在CNV发病中的作用及其机制,是未来CNV发病机制研究的重要方向。本综述旨在阐述miRNA调控CNV中的磷脂酰肌醇3激酶/丝氨酸/苏氨酸蛋白激酶B(PI3K/Akt)、转化生长因子-β(TGF-β)、核因子-κB(NF-κB)、Notch及Wnt信号通路,为阐明CNV发病机制及其靶向治疗提供新思路。Choroidal neovascularization(CNV)is the ultimate pathological manifestation of various ocular diseases.Its pathogenesis is extremely complex and involves multiple cells,cytokines,and signaling pathways.MicroRNA(miRNA),as a kind of small biological molecules,is a non-coding RNA composed of 22 nucleotides that regulates gene expression by degrading or inhibiting mRNA translation of target genes.Having been increasingly studied and their involvement in the development of various diseases through miRNA-mediated signaling pathways have been revealed.In the field of ophthalmology,miRNA target specific protein genes through various signaling pathways to promote or inhibit CNV.Therefore,revealing the role and mechanism of miRNA in the pathogenesis of CNV is an important direction of future research on the pathogenesis of CNV.This article aims to review on phosphatidylinositol 3 kinase-protein kinase B(PI3K-Akt),transforming growth factor-beta(TGF-β),nuclear factor-kappa B(NF-κB),Notch and Wnt signaling pathways in miRNA regulation of CNV,providing new insights into the pathogenesis of CNV and targeted therapy for CNV.

关 键 词：脉络膜新生血管 微小RNA 信号通路 血管内皮生长因子 骨髓来源细胞 

分 类 号：R773.4[医药卫生—眼科]