代谢组学在眼部疾病中的研究进展  

Advances of metabolomics in ocular diseases

作　　者：蒋佳璇 刘俊鹏 欧阳珺雯 张成晓 胡凯[1] Jiang Jiaxuan;Liu Junpeng;Ouyang Junwen;Zhang Chengxiao;Hu Kai(Department of Ophthalmology,Nanjing Drum Tower Hospital,the Affiliated Hospital of Medical School,Nanjing University,Nanjing 210008,Jiangsu Province,China)

机构地区：[1]南京大学医学院附属鼓楼医院眼科,中国江苏省南京市210008

出　　处：《国际眼科杂志》2024年第3期420-426,共7页International Eye Science

基　　金：江苏省自然科学基金(No.BK20201114);南京鼓楼医院临床专项(No.2022-LCYJ-MS-36)。

摘　　要：眼部疾病是全球的重要健康问题。代谢组学是对一个系统中的代谢物进行识别和定量的新兴研究技术,可用于阐明疾病机制及识别新的生物标志物,为深入探究眼部疾病的发生和发展提供了新的策略。本文简介了代谢组学的基本技术,汇总分析了代谢组学在糖尿病视网膜病变、年龄相关性黄斑变性、青光眼和干眼四种眼部疾病中的最新研究进展,总结了潜在的生物标志物和代谢途径,并对代谢组学在未来眼部疾病管理和治疗中的应用前景进行了展望。Ocular diseases pose a significant challenge to global health.The field of metabolomics,which involves the systematic identification and quantification of metabolites within a biological system,has emerged as a promising research approach for unraveling disease mechanisms and discovering novel biomarkers.Through its application,metabolomics has yielded valuable knowledge pertaining to the initiation and advancement of various ocular diseases.This review presents an overview of metabolomics and examines recent research progess in four ocular diseases,specifically diabetic retinopathy,age-related macular degeneration,glaucoma,and dry eye,summarizing potential biomarkers and metabolic pathways associated with these diseases.Additionally,this review offers insights into the future prospects of utilizing metabolomics for the management and treatment of ocular diseases.

关 键 词：代谢组学 眼部疾病 糖尿病视网膜病变 年龄相关性黄斑变性 青光眼 

分 类 号：R77[医药卫生—眼科]