世界卫生组织《结核分枝杆菌耐药相关基因突变目录(第2版)》解读  

Interpretation of the World Health Organization’s Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance(2nd Edition)

作　　者：裴少君 欧喜超[2] Pei Shaojun;Ou Xichao(Department of Global Health,School of Public Health,Peking University,Beijing 100191,China;National Center for Tuberculosis Control and Prevention,National Key Laboratory of Intelligent Tracking and Forecasting for Infectious Diseases,Chinese Centre for Disease Control and Prevention,Beijing 102206,China)

机构地区：[1]北京大学公共卫生学院全球卫生学系,北京100191 [2]中国疾病预防控制中心传染病溯源预警与智能决策全国重点实验室结核病预防控制中心,北京102206

出　　处：《中国防痨杂志》2024年第3期260-266,共7页Chinese Journal of Antituberculosis

基　　金：国家重点研发计划(2022YFC2305204)。

摘　　要：耐药结核病是2035年实现全球终结结核病流行目标的巨大障碍。世界卫生组织(World Health Organization,WHO)倡导采用快速分子药物敏感性检测技术进行耐药结核病早期诊断,而覆盖全面可靠的耐药检测靶标是提高分子药物敏感性检测技术可靠性的关键。WHO于2023年11月发布《结核分枝杆菌耐药相关基因突变目录(第2版)》,目的是基于更广泛的全球数据汇总形成更为全面准确的耐药相关基因突变目录,为开发与完善基于测序或其他方法的新型分子药物敏感性检测技术提供支持。本文对第2版目录相较于第1版目录在分析流程与耐药突变等内容的更新进行了详细的解读,并对未来目录完善的方向进行了展望。Drug-resistant tuberculosis is a major obstacle to the achievement of the End TB Strategy by 2035.The World Health Organization(WHO)promotes the use of rapid molecular drug susceptibility testing technology for early diagnosis of drug-resistant tuberculosis.Covering comprehensive and reliable drug resistance-related mutations is the key to improving the reliability of molecular drug resistance diagnosis.WHO has released the second edition of the Catalogue of mutations in Mycobacterium tuberculosis complex and their association with drug resistance in November 2023.This catalogue described more comprehensive and accurate drug-resistance-related gene mutations based on the largest collection of multinational Mycobacterium tuberculosis complex isolates,so as to support the development and improvement of the molecular drug susceptibility testing technology.This article provides a detailed interpretation of the updates in the analysis process and drug-resistant mutations in the second edition of the catalogue compared with the first edition,and looks forward to the future direction of improving the catalogue.

关 键 词：分枝杆菌 结核 抗药性 细菌 微生物敏感性试验 基因 突变 

分 类 号：R378.91[医药卫生—病原生物学] R446[医药卫生—基础医学]