荜铃胃痛颗粒联合雷贝拉唑对胃食管反流患者食管动力学的影响  

Effect of Biling Weitong granules combined with rabeprazole on esophageal dynamics in patients with gastroesophageal reflux

作　　者：黄国彬 彭薇淇 HUANG Guobin;PENG Weiqi(Department of Geriatrics,Baiyun Branch of Nanfang Hospital,Southern Medical University,Guangzhou 510000,China;不详)

机构地区：[1]南方医科大学南方医院白云分院老年病科,广州市510000 [2]南方医科大学南方医院白云分院消化内科,广州市510000

出　　处：《临床合理用药杂志》2024年第5期7-10,共4页Chinese Journal of Clinical Rational Drug Use

基　　金：广州市白云区2020年度医疗卫生科技计划项目(2020-YL-008)。

摘　　要：目的 观察荜铃胃痛颗粒联合雷贝拉唑对胃食管反流(GER)患者食管动力学的影响。方法 选取2020年6月—2021年6月南方医科大学南方医院白云分院收治的GER患者160例,依据随机数字表法分为观察组(n=80)和对照组(n=80)。对照组给予雷贝拉唑治疗,观察组在对照组基础上给予荜铃胃痛颗粒治疗,2组均治疗8周。比较2组临床疗效,治疗前后临床症状评分、食管动力学指标[食管上段括约肌(UES)压力、食管下段括约肌(LES)压力]及不良反应。结果 观察组总有效率为95.00%,高于对照组的85.00%(χ^(2)=4.444,P=0.035)。治疗8周后,2组胃灼感、反酸、反食评分低于治疗前,且观察组低于对照组(P<0.01);2组UES与LES压力高于治疗前,且观察组高于对照组(P<0.01)。观察组与对照组不良反应总发生率比较差异无统计学意义(11.25%vs. 7.50%,χ^(2)=0.662,P=0.416)。结论 荜铃胃痛颗粒联合雷贝拉唑可提高疗效,有效改善GER患者临床症状及食管动力学,且未明显增加不良反应。Objective To observe the effect of Biling Weitong granules combined with rabeprazole on esophageal dynamics in patients with gastroesophageal reflux(GER).Methods A total of 160 patients with GER admitted to Baiyun Branch of Nanfang Hospital,Southern Medical University from June 2020 to June 2021 were selected and randomly divided into the observation group(n=80)and the control group(n=80)according to the random number table method.The control group was treated with rabeprazole,and the observation group was treated with Biling Weitong granules on the basis of the control group.The two groups were treated for 8 weeks.The clinical efficacy,clinical symptom scores,esophageal dynamics indexes(UES,LES)before and after treatment and adverse reactions between the two groups were compared.Results The total effective rate of the observation group was 95.00%,which was higher than 85.00%of the control group(χ^(2)=4.444,P=0.035).After 8 weeks of treatment,the scores of heartburn,acid regurgitation and food regurgitation in the two groups were lower than those before treatment,and those in the observation group were lower than those in the control group(P<0.01).The UES and LES pressures of the two groups were higher than those before treatment,and the observation group was higher than the control group(P<0.01).There was no significant difference in the total incidence of adverse reactions between the observation group and the control group(11.25%vs.7.50%,χ^(2)=0.662,P=0.416).Conclusion Biling Weitong granules combined with rabeprazole can improve the curative effect,effectively improve the clinical symptoms and esophageal dynamics in patients with GER,without significantly increasing adverse reactions.

关 键 词：胃食管反流 荜铃胃痛颗粒 雷贝拉唑 食管动力学 

分 类 号：R571[医药卫生—消化系统]