Rare peptide anchors of HLA class I alleles contribute to the COVID-19 disease severity and T cell memory  

作　　者：Xin Wang Jie Zhang Peipei Guo Yuanyuan Guo Xiaonan Yang Maoshun Liu Danni Zhang Yaxin Guo Jianbo Zhan Kun Cai Jikin Zhou Shaobo Dong Jun Liu 

机构地区：[1]Department of Epidemiology,School of Public Health,Cheeloo College of Medicine,Shandong University,Jinan 250012,China [2]NHC Key Laboratory of Biosafety,Research Unit of Adaptive Evolution and Control of Emerging Viruses,Chinese Academy of Medical Sciences,National Institute for Viral Disease Control and Prevention,Chinese Center for Disease Control and Prevention(China CDC),Beijing 102206,China [3]Beijing Key Laboratory of Emerging Infectious Diseases,Institute of Infectious Diseases,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China [4]Beijing Institute of Infectious Diseases,Beijing 100015,China [5]National Center for Infectious Diseases,Beijing Ditan Hospital,Capital Medical University,Beijing 100015,China [6]School of Laboratory Medicine and Life Sciences,Wenzhou Medical University,Wenzhou 325035,China [7]Hubei Provincial Center for Disease Control and Prevention,Wuhan 430079,China [8]Shijiazhuang Fifth Hospital,Shijiazhuang 050011,China [9]Macheng Center for Disease Control and Prevention,Huanggang 438300,China

出　　处：《Biosafety and Health》2023年第6期355-362,共8页生物安全与健康（英文）

基　　金：The National Key Research and Development Program of China (2022YFC2604100);the National Natural Science Foundation of China (92269203)supported the study.

摘　　要：Understanding how human leukocyte antigen(HLA)polymorphism affects both the susceptibility and severity of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)infection will help to identify individuals at higher risk to better manage and prioritize vaccination at the clinical level and explain the differences in epidemic trends in different regions at the epidemiological level.This study compared the frequencies of HLA class I alleles(HLA-A,B)in 214 coronavirus disease 2019(COVID-19)patients with different disease severity and 35 healthy controls and analyzed the correlations between specific HLA alleles and disease severity and T cell memory.The results showed no significant difference in HLA allele frequencies between COVID-19 patients and healthy controls(P>0.05).The allele HLA-B*13:02 was significantly correlated with the disease severity of COVID-19 patients(P=0.006).After adjustment for age and disease severity,the T cell responses of COVID-19 convalescents with the allele HLA-B*40:01 may be lower at six months(P=0.044)and 12 months(P=0.069).Moreover,these results may be due to their rare peptide anchors by analyzing the binding peptide motifs of these HLA alleles.The study may be valuable for investigating the potential association of specific HLA alleles with SARS-CoV-2 infection.

关 键 词：SARS-CoV-2 COVID-19 HLA SUSCEPTIBILITY Disease severity 

分 类 号：R563.1[医药卫生—呼吸系统]