铜稳态与铜死亡在中枢神经系统疾病中的研究进展  

Recent advance in role of copper homeostasis and copper death in central nervous system diseases

作　　者：朱志鹏 宋闽 任建勋 梁礼嵘 程祖珏[1] 毛国华[1] 陈敏[1] Zhu Zhipeng;Song Min;Ren Jianxun;Liang Lirong;Cheng Zujue;Mao Guohua;Chen Min(Department of Neurosurgery,Second Affiliated Hospital of Nanchang University,Nanchang 330006,China)

机构地区：[1]南昌大学第二附属医院神经外科,南昌330006

出　　处：《中华神经医学杂志》2023年第12期1277-1281,共5页Chinese Journal of Neuromedicine

基　　金：国家自然科学基金(82160243);江西省教育厅科学技术研究项目(GJJ210171);江西省卫生健康委科技计划项目(202210596)。

摘　　要：作为生物体内的必需微量元素,铜积极参与各系统正常生理过程并被维持在低水平,以实现铜稳态。铜稳态一旦被打破将诱导细胞死亡,这种新的细胞死亡形式被称为铜死亡。近年来,铜死亡越来越被认为是介导中枢神经系统(CNS)疾病发病和进展的重要因素,故本文围绕铜死亡在CNS疾病中的致病机制以及相应治疗策略进行综述,以期加深研究人员对其的了解。As an essential trace element in living organisms,copper is actively involved in normal physiological processes in various systems and is maintained at low level to achieve copper homeostasis.Copper homeostasis,once being disrupted,would induce cell death,and this new form of cell death is known as copper death.In recent years,copper death has been increasingly recognized as an important factor mediating the onset and progression of central nervous system(CNS)diseases.Therefore,we review the pathogenic mechanism of copper death in CNS diseases,as well as its therapeutic strategies so as to deepen the understanding of researchers.

关 键 词：铜稳态 铜死亡 中枢神经系统疾病 

分 类 号：R741[医药卫生—神经病学与精神病学]