阿尔茨海默病与铁死亡相关性的研究进展  

Research Progress on the Relevance between Alzheimer’s Disease and Ferroptosis

作　　者：张洪铭 冯丽娜 孙保亮 ZHANG Hongming;FENG Lina;SUN Baoliang(College of Traditional Chinese Medicine,Shandong University of Traditional Chinese Medicine,Jinan 250355,China;The Second Affiliated Hospital,Shandong First Medical University&Shandong Academy of Medical Sciences,Shandong Taian,271099,China;School of Clincal and Basic Medicine of Shandong First Medical University&Shandong Academy of Medical Sciences,Shandong Taian,271016,China)

机构地区：[1]山东中医药大学,济南250355 [2]山东第一医科大学(山东省医学科学院)第二附属医院,山东泰安271099 [3]山东第一医科大学(山东省医学科学院)临床与基础医学院,山东泰安271016

出　　处：《神经损伤与功能重建》2024年第2期105-108,共4页Neural Injury and Functional Reconstruction

基　　金：山东第一医科大学(山东省医学科学院)学术提升计划(神经系统疾病防治新靶点及干预,No.2019QL016)。

摘　　要：阿尔茨海默病(Alzheimer’s disease,AD)是最常见的痴呆类型,是以进行性认知功能障碍为主要表现的神经系统退行性病变。调节性细胞死亡是基因决定的细胞主动有序的死亡,普遍存在于在生命体发育过程中,对调节生命稳态至关重要。随着调节性细胞死亡在AD的广泛研究,越来越多的证据揭示铁死亡与AD的发生、发展以及转归密切相关。本文将对铁死亡的分子机制及其在AD中的调控作用进行综述,为AD的发病机制和治疗探索潜在治疗靶点。Alzheimer’s disease(AD)is the most common type of dementia,characterized by progressive cognitive dysfunction as a primary manifestation of neurodegenerative changes.Regulated cell death,an active and orderly form of cell demise determined by genetic factors,is ubiquitous during the development of living organisms and is crucial for maintaining life homeostasis.With extensive research on regulated cell death in AD,increasing evidence reveals that ferroptosis is closely related to the onset,progression,and outcome of AD.This article will review the molecular mechanisms of ferroptosis and its regulatory role in AD,providing insights into potential therapeutic targets for exploring the pathogenesis and treatment of AD.

关 键 词：阿尔茨海默病 铁死亡 铁代谢紊乱 脂质过氧化 综述 

分 类 号：R741[医药卫生—神经病学与精神病学] R741.02[医药卫生—临床医学] R742