铜死亡与乳腺癌相关性的研究进展  

Research progress on the relationship between cuproptosis and breast cancer

作　　者：任黎蕾 赵小波[1] 高砚春[1] 侯令密[1] REN Lilei;ZHAO Xiaobo;GAO Yanchun;HOU Lingmi(Department of Breast Surgery,Affiliated Hosptial of North Sichuan Medical College,Nanchong,Sichuan 637000,P.R.China)

机构地区：[1]川北医学院附属医院乳腺外科,四川南充637000

出　　处：《中国普外基础与临床杂志》2024年第2期250-256,共7页Chinese Journal of Bases and Clinics In General Surgery

摘　　要：目的总结铜及铜死亡机制在乳腺癌领域的最新进展,为临床治疗决策提供参考。方法查阅近年来铜及铜死亡相关文献,对铜在乳腺癌中的作用及铜死亡机制应用于乳腺癌诊疗的研究进展进行综述。结果铜死亡是新发现的一种程序性细胞死亡形式,通过与三羧酸循环的脂酰化成分相结合,导致脂酰化蛋白质聚集和随后的铁簇硫蛋白丢失,从而导致蛋白质毒性应激并最终导致细胞死亡。铜死亡可诱导乳腺癌细胞的增殖和迁移,介导个性化免疫治疗,参与内分泌治疗及化疗药物耐药。结论铜死亡在乳腺癌后续免疫治疗、内分泌治疗及化疗中具有潜在的应用前景,可能为乳腺癌患者带来新的有效策略。Objective To summarize the latest advances in copper and cuproptosis in the field of breast cancer,and to provide a reference for clinical treatment decisions.Method The literatures related to copper and cuproptosis in recent years were read and summarized,and the research progress on the role of copper in breast cancer,the application of cuproptosis in the diagnosis and treatment of breast cancer were reviewed.Results Cuproptosis was a novel form of programmed cell death,which occurred via direct binding of copper to lipoylated components of the tricarboxylic acid(TCA)cycle,this resulted in lipoylated protein aggregation and subsequent iron-sulfur cluster protein loss,leading to proteotoxic stress and ultimately cell death.Cuproptosis induced proliferation and migration of breast cancer cell,mediated personalized immunotherapy,and participated in endocrine and chemotherapeutic drug resistance.Conclusion Exploring the mechanism of cuproptosis provides potential applications for subsequent immunotherapy,endocrine therapy,and chemotherapy for breast cancer,leading to new effective strategies for patients.

关 键 词：铜死亡 乳腺癌 免疫治疗 耐药 机制 

分 类 号：R737.9[医药卫生—肿瘤]