Pan-cancer analysis of RNA 5-methylcytosine reader (ALYREF)  

作　　者：XING YE ZHOUTING TUO KAI CHEN RUICHENG WU JIE WANG QINGXIN YU LUXIA YE AKIRA MIYAMOTO KOO HAN YOO CHI ZHANG WURAN WEI DENGXIONG LI DECHAO FENG 

机构地区：[1]Samuel Oschin Comprehensive Cancer Institute,Department of Medicine,Department of Biomedical Sciences,Cedars-Sinai Medical Center,Los Angeles,CA,90048,USA [2]Department of Urology,The Second Afiliated Hospital of Anhui Medical University,Hefei,230601,China [3]Department of Urology,Institute of Urology,West China Hospital,Sichuan University,Chengdu,610041,China [4]Department of Pathology Ningbo Diagnostic Pathology Center,Ningbo,315021,China [5]Department of Public Research Platfom,Taizhou Hospital of Zhejiang Province Afliated to Wenzhou Medical University,Linhai,317000,China [6]Department of Rehabilitation,West Kyushu University,Kanzaki shi,842-8585,Japan [7]Department of Urology,Kyung Hee University,Seoul,446701,South Korea [8]Department of Rehabilitation,The Afliated Hospital of Southwest Medical University,Luwzhou,646000,China

出　　处：《Oncology Research》2024年第3期503-515,共13页肿瘤学研究（英文）

基　　金：the Chinese Scholarship Council(Grant No.202206240086);the National Natural Science Foundation of China(Grant No.82170432);programs from Science and Technology Department of Sichuan Province(Grant No.2020YFSY0024).

摘　　要：The incre asing interest in RNA modifications has signifcantly advanced epigenomic and epitranscriptomic technologies.This study focuses on the immuno oncological impact of ALYREF in human cancer through a pan-cancer analysis,enhancing understanding of this gene's role in cancer.We observed differential ALYREF expression between tumor and normal samples,correl ating strongly with prognosis in various cancers,particularly kidney renal papillary cell carcinoma(KIRP)and liver hepatocellular carcinoma(LIHC).ALYREF showed a negative correlation with most tumor-infitrating cells in lung squamous cell carcinoma(LUSC)and lymphoid neoplasm difuse large B-cell lymphoma(DLBC),while positive correlations were noted in IIHC,kidney chromophobe(KICH),mesothelioma(MESO),KIRP,pheochromocytoma and paraganglioma(PARD),and glioma(GBMLGG).Aditionally,ALYREF expression was closely associated with tumor heterogeneity,stemness indices,and a high mutation rate in TP53 across these cancers.In conclusion,ALYREF may serve as an oncogenic biomarker in numerous cancers,meriting further research attention.

关 键 词：Pan-cancer RNA 5-methylcytosine ALYREF Immwno-oncological efects 

分 类 号：R730[医药卫生—肿瘤]