线粒体与青光眼关系的研究进展  

Research Progress on the Relationship Between Mitochondria and Glaucoma

作　　者：石晶博 马林慧 李彬[1] 石荣先[1] SHI Jingbo;MA Linhui;LI Bin;SHI Rongxian(The First Affiliated Hospital of Henan University,Kaifeng 475004,China)

机构地区：[1]河南大学第一附属医院,开封475004

出　　处：《中国中医眼科杂志》2024年第2期186-190,共5页China Journal of Chinese Ophthalmology

基　　金：开封市科技发展计划项目(2203035)。

摘　　要：青光眼是以特征性视神经损伤和视野缺损为主要表现的一类眼病,其本质是视网膜神经节细胞(RGC)的损伤。原发性开角型青光眼和原发性闭角型青光眼的原发部位是小梁网,线粒体介导的氧化应激是青光眼患者RGC损伤和人眼小梁网细胞(HTMC)死亡的关键。本文就青光眼患者的线粒体基因改变、HTMC和RGC的线粒体氧化应激机制、中药通过氧化应激途径治疗青光眼的机制以及线粒体自噬与青光眼的关系展开综述,从线粒体介导的分子机制层面去认识青光眼的病理机制,为研发青光眼新的药物靶点提供方向。Glaucoma is a class of eye diseases characterized by characteristic optic nerve damage and visual field defects,primarily resulting from injury to retinal ganglion cell(RGC).The primary site of origin for primary open-angle glaucoma and primary angle-closure glaucoma is the trabecular meshwork,and mitochondrial-mediated oxidative stress is crucial in the damage of RGC in glaucoma patients and the death of human trabecular meshwork cells(HTMC).This article provides a comprehensive review of mitochondrial genetic changes in glaucoma patients,the mito-chondrial oxidative stress mechanisms in HTMC and RGC,the mechanisms through which Tradi-tional Chinese Medicine treats glaucoma via the oxidative stress pathway,and the relationship be-tween mitochondrial autophagy and glaucoma.By understanding the molecular mechanisms medi-ated by mitochondria,this review aims to shed light on the pathological mechanisms of glaucoma and provide directions for developing new medicine targets for glaucoma.

关 键 词：青光眼 线粒体 视网膜神经节细胞 人眼小梁网细胞 氧化应激 线粒体自噬 

分 类 号：R775[医药卫生—眼科]