血小板升高对胃癌预后的影响:系统评价和荟萃分析  

The effect of elevated platelet on the prognosis of gastric cancer:a systematic review and Meta-analysis

作　　者：朱丽慧 刘硕 蔡辉 ZHU Lihui;LIU Shuo;CAI Hui(The First School of Clinical Medicine,Ningxia Medical University,Yinchuan 750000;NHC Key Laboratory of Diagnosis and Therapy of Gastrointestinal Tumor,Gansu Provincial Hospital;Gansu Key Laboratory of Molecular Diagnostics and Precision Medicine for Surgical Oncology,Gansu Provincial Hospital;The First Clinical Medical College of Lanzhou University,China)

机构地区：[1]宁夏医科大学第一临床医学院,宁夏银川750000 [2]甘肃省人民医院国家卫生健康委胃肠肿瘤诊疗重点实验室 [3]甘肃省人民医院甘肃省外科肿瘤分子诊断与精准医学重点实验室 [4]兰州大学第一临床医学院

出　　处：《胃肠病学和肝病学杂志》2024年第2期177-183,共7页Chinese Journal of Gastroenterology and Hepatology

摘　　要：目的探讨血小板对胃癌患者预后情况的预测价值。方法分别在PubMed、EmBase、Web of Science和Cochrane图书馆进行全面系统的检索,由两名独立的评审员进行文献筛选和数据提取工作。处理后的数据采用随机效应模型进行汇总,并用HR值来描述OS的合并结果,用OR值来描述临床病理事件发生的可能性。同时对整体进行敏感性分析和偏倚分析检测研究结果的稳定性及是否存在偏倚风险。结果共筛选出26篇文献,总计21076例患者被纳入荟萃分析。研究结果显示:血小板升高与胃癌预后之间有显著相关性(HR=1.41,95%CI:1.24~1.61)。亚组分析结果并未影响整体结果。临床病理特征间的分析表明血小板升高与胃癌中女性(OR=1.54,95%CI:1.39~1.70)、T分期(OR=2.22,95%CI:1.98~2.49)、淋巴结转移(OR=1.51,95%CI:1.36~1.68)、TNM分期(OR=1.84,95%CI:1.60~2.11)以及肿瘤大小(OR=2.16,95%CI:1.83~2.56)相关。结论血小板计数对胃癌的预后有显著预测价值,且与临床病理晚期、淋巴结转移风险高相关。Objective To explore the predictive value of PLT on the prognosis of gastric cancer patients.Methods The 4 major English databases,PubMed,Embase,Web of Science and the Cochrane Library,were each thoroughly and methodically searched.The literature screening and data extraction process was then carried out by 2 independent reviewers.The processed data we pooled using a random effects model and finally described the combined outcome of OS with HR value and the likelihood of a clinicopathological event with OR value.We also performed overall sensitivity analysis and bias analysis to detect the stability of the study results and the risk of bias.Results For the Meta-analysis,a total of 26 studies involving 21076 participants underwent screening.The results of the study showed a significant correlation between increased PLT and prognosis of gastric cancer(HR=1.41,95%CI:1.24-1.61).The results of subgroup analysis did not affect the overall results.Analysis between clinicopathological features showed that increased PLT were associated with female(OR=1.54,95%CI:1.39-1.70),T stage(OR=2.22,95%CI:1.98-2.49),lymph node metastasis(OR=1.51,95%CI:1.36-1.68),TNM stage(OR=1.84,95%CI:1.60-2.11)and tumor size(OR=2.16,95%CI:1.83-2.56)were associated.Conclusion PLT has a significant predictive value for the prognosis of gastric cancer and is associated with advanced clinicopathological stage and high risk of lymph node metastasis.

关 键 词：胃癌 血小板计数 荟萃分析 预后 

分 类 号：R735.2[医药卫生—肿瘤]