PAR-2的活化致肠易激综合征发生机制的研究进展  

Advances in the mechanism of action of PAR-2 activation in irritable bowel syndrome

作　　者：许鏸文 雷源 何婷 李娟娟 宋姗姗 古巧燕[1] XU Huiwen;LEI Yuan;HE Ting;LI Juanjuan;SONG Shanshan;GU Qiaoyan(Department of Gastroenterology,Affiliated Hospital of Yan′an University,Yan′an 716000,China)

机构地区：[1]延安大学附属医院消化内科,陕西延安716000

出　　处：《胃肠病学和肝病学杂志》2024年第2期197-200,共4页Chinese Journal of Gastroenterology and Hepatology

摘　　要：肠易激综合征(irritable bowel syndrome,IBS)是一种常见的功能性肠道疾病,其主要特征包括下腹痛、排便性状、习惯改变等。由于IBS极大降低患者生活质量并给患者造成巨大经济压力,其发病机制及治疗已成为诸多学者的研究重点,被认为是内脏敏感性、胃肠动力异常、肠道感染、精神心理障碍等共同作用的结果。近年有研究表明,蛋白酶激活受体2(protease activated receptor 2,PAR-2)与IBS密切相关,PAR-2通过其活化以及信号通路等多种方式影响IBS的发生发展,本文就以PAR-2与IBS发生的关系进行综述。Irritable bowel syndrome(IBS)is a common functional intestinal disorder,mainly including lower abdomen pain,bowel behavior and habit changes and other symptoms.As IBS greatly reduces the quality of life of patients and causes great economic pressure to patients,its pathogenesis and treatment have become the focus of many scholars,which is considered to be the result of the combined action of visceral sensitivity,gastrointestinal motility abnormalities,intestinal infection and mental and psychological disorders.In recent years,studies have shown that protease activated receptor 2(PAR-2)is closely related to IBS.PAR-2 has been found to affect the occurrence and development of IBS through its activation and signaling pathways.In this paper,the relationship between PAR-2 and IBS occurrence was reviewed.

关 键 词：肠易激综合征 蛋白酶激活受体2 内脏高敏感 信号通路 

分 类 号：R574[医药卫生—消化系统]