多线耐药骨肉瘤脑转移1例  

The brain metastasis of multi-line drug-resistant osteosarcoma:a case report

作　　者：陈惠东 余文熙 Chen Huidong;Yu Wenxi(Department of Oncology,Shanghai Sixth People′s Hospital Afliated to Shanghai Jiao Tong University School of Medicine,Shanghai 200080,China)

机构地区：[1]上海交通大学医学院附属第六人民医院肿瘤科,上海200080

出　　处：《中华转移性肿瘤杂志》2023年第4期457-460,共4页Chinese Journal of Metastatic Cancer

摘　　要：骨肉瘤是青少年最常见的原发性恶性骨肿瘤,恶性程度高,早期易发生远处转移;骨肉瘤的常见转移部位为肺,其次为骨骼。随着近30年骨肉瘤综合治疗模式的开展,患者无瘤/带瘤生存期大幅度提高,远处转移的类型也有所改变;此外,新的影像学检查手段的广泛应用也提高了骨肉瘤罕见转移灶的阳性发现率。脑转移在骨肉瘤的病程中相对较为少见,目前其诊疗尚无标准共识。我科于2020年接诊1例左颞下颌软骨母细胞型骨肉瘤伴脑部临近转移的患者,现结合文献进行相关病例及治疗经验的讨论。Osteosarcoma(OS),the most common malignant tumor in the musculoskeletal system,mainly occurs in adolescents.OS has high degree of malignancy and develops distant metastasis to lung and bone in early stage.In recent 30 years,with the development of comprehensive treatment consisting of surgery and chemotherapy,the prognosis of OS has a promising improvement.In addition,the finding of rare metastasis of osteosarcoma is increased by the widespread application of new imaging examination.Brain metastasis of osteosarcoma is rare,and the diagnosis and treatment is still heterogeneous in literatures without consensus.Here we present a case of left temporal mandible osteosarcoma with brain metastasis in a middle-aged male undergoing multi-line treatment with cadonilimab,an anti-PD-1/CTLA-4 bispecific antibody.

关 键 词：软骨母细胞型骨肉瘤 脑转移 化疗耐药 

分 类 号：R738.1[医药卫生—肿瘤]