饮食中黄酮类化合物摄入量与人体总骨矿物质含量的关联性分析  

Analysis of the relationship between dietary flavonoid intake and total bone mineral content in human body

作　　者：马国琛 胡一凡 字璟 李昊奇 曾雅贤 罗航 徐珏 熊静远 MA Guo-chen;HU Yi-fan;ZI Jing;LI Hao-qi;ZENG Ya-xian;LUO Hang;XU Jue;XIONG Jing-yuan(West China School of Public Health,Sichuan University/West China Fourth Hospital,Chengdu,Sichuan 610041,China)

机构地区：[1]四川大学华西公共卫生学院/华西第四医院,四川成都610041

出　　处：《现代预防医学》2024年第3期433-438,共6页Modern Preventive Medicine

基　　金：四川省科技厅应用基础项目(2021YJ0156)。

摘　　要：目的探讨饮食中黄酮类化合物的摄入与人体总骨矿物质含量之间的关系。方法选择2017—2018年美国国家健康和营养调查(NHANES)中20~59岁成年人作为研究对象,通过构建多变量线性回归模型,对性别、年龄、种族、受教育水平、婚姻状况、经济情况、BMI、饮酒情况、高血压、糖尿病及心血管疾病进行调整,探究饮食中黄酮类化合物摄入量和人体总骨矿物质含量之间的关系。结果研究共纳入2110人,男女比例约为1:1,平均总矿物质含量为2341.4 g,饮食中总黄酮摄入量的中位数为74.45 mg。在调整了性别、年龄、种族、受教育水平、婚姻状况、经济情况、BMI、饮酒情况、高血压、糖尿病和心血管疾病后的线性回归模型显示全身总骨矿物质含量与饮食中异黄酮摄入量呈正相关(β=0.68,95%CI:0.26~1.09),并存在剂量反应关系(Ptrend=0.001),此外,亚组分析结果表明,该正相关关系在男性中更为强烈[男性(β=1.39,95%CI:0.67~2.11)vs.女性(β=0.18,95%CI:-0.31~0.67),Pinter=0.038]。结论饮食中异黄酮摄入可能会增加人体全身总骨矿物质的含量,但是否具有性别差异仍需进一步探究。Objective To investigate the relationship between the intake of flavonoids in diet and total bone mineral content in human body.Methods Adults aged 20 to 59 years in the National Health and Nutrition Examination Surveys(NHANES)from 2017 to 2018 were selected as research subjects.A multivariate linear regression model was constructed to explore the relationship between dietary flavonoid intake and total bone mineral content adjusting gender,age,race,education level,marital status,economic status,BMI,alcohol consumption,hypertension,diabetes,and cardiovascular disease.Results A total of 2110 participants were included in the study,with the ratio of male to female 1:1.The average total mineral content was 2341.4 g,and the median intake of total flavonoids in diet was 74.45 mg.After adjusting for sex,age,race,education,marital status,economic status,BMI,alcohol consumption,hypertension,diabetes and cardiovascular disease,the linear regression model showed that the total bone mineral content of the whole body was positively correlated with dietary isoflavone intake(β=0.68,95%CI:0.26-1.09),and there was a dose-response relationship(Ptrend=0.001).In addition,the results of subgroup analysis showed that the positive correlation was stronger in men(βmale=1.39,95%CI:0.67-2.11 vs.βFemale=0.18,95%CI:-0.31 to 0.67,Pinter=0.038).Conclusion the intake of isoflavones in diet may increase the content of total bone minerals in human body,but whether there is a gender difference needs to be further explored.

关 键 词：黄酮类化合物 异黄酮 总骨矿物质含量 

分 类 号：R151.4[医药卫生—营养与食品卫生学]