逃离导向基团:非活化烯烃的不对称碳-碳键构筑  

Escaping from directing groups:Enantioselective C–C bond construction from unactivated olefins

作　　者：Hongyu Zhong Bill Morandi 

机构地区：[1]Laboratorium für Organische Chemie,ETH Zürich,Zürich 8093,Switzerland

出　　处：《Science Bulletin》2024年第3期290-292,共3页科学通报（英文版）

摘　　要：Unfunctionalized olefins are produced on an enormous scale in the petroleum industry.For example,propene and butenes are produced annually on over 100-and 40-million-ton scales.Transition metal catalysis is an attractive approach for the valorization of such chemical feedstocks,which provides value-added building blocks that can be further transformed into pharmaceuticals and functional materials.However,unfunctionalized olefins are relatively inert molecules due to their weak interaction with the metal centers.Accordingly,the functionalization of unactivated olefins has been a long-standing challenge in transition metal catalysis.The use of directing groups has become a universal strategy to overcome the reactivity and selectivity issues[1].Directing groups are strongly binding functionalities that serve to coordinate to the metal center and bring the unactivated moiety closer to the metal.

关 键 词：MOIETY OVERCOME CLOSER 

分 类 号：O623.12[理学—有机化学] O641.2[理学—化学]