口腔微生物组与肺癌发生、发展的研究现状与展望  

Current status and prospects of the relationship between oral microbiome and the occurrence and development of lung cancer

作　　者：马琼 曾潇 李雪珂 由丽婷 付西 由凤鸣[1,2] 任益锋 Qiong Ma;Xiao Zeng;Xueke Li;Liting You;Xi Fu;Fengming You;Yifeng Ren(TCM Regulating Metabolic Diseases Key Laboratory of Sichuan Province,Hospital of Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;Cancer Institute,Chengdu University of Traditional Chinese Medicine,Chengdu 610075,China;Department of Laboratory Medicine,West China Hospital,Sichuan University,Chengdu 610041,China)

机构地区：[1]成都中医药大学附属医院,代谢性疾病中医药调控四川省重点实验室,成都610075 [2]成都中医药大学肿瘤研究所,成都610075 [3]四川大学华西医院检验科,成都610041

出　　处：《科学通报》2024年第3期381-393,共13页Chinese Science Bulletin

基　　金：四川省科技厅重大科技专项(2022ZDZX0022);中央引导地方科技发展项目(2022ZYD0100)资助。

摘　　要：“微生物组在健康和疾病中扮演什么角色?”这一热点话题作为全世界最前沿的125个科学问题之一,近年来持续受到了广泛关注.口腔内含有位点特异性微生物组已是共识,其与宿主细胞的相互作用调节了机体多种生理病理过程.新近证据表明,口腔微生态失调与肺癌风险具有密切的联系,特定口腔微生物及其代谢产物可通过直接/间接的机制在促进或阻延肺癌发生、发展中扮演了重要角色,如诱导炎性微环境、促进肿瘤细胞免疫逃逸和影响细胞相关增殖凋亡信号通路等.上述研究亦支持了口腔微生物在肺癌临床诊疗中的应用潜力.据此,本综述旨在概述口腔微生物组-肺癌研究的前沿进展,探讨当前存在的问题和未来的发展方向,以期激发研究者对这一新兴领域更大的兴趣和更深入的研究.The occurrence and development of lung cancer involve a complex process that is affected by genetic factors and external stimuli.Lung cancer events induced by environmental factors are more common than those due to genetic factors.The microbiome is an environmental stimulator that plays a vital role in human health and disease,and it has received extensive attention in the past few decades.As one of the most diverse and abundant microbial communities in the human body,the oral microbiome is also the main source of microbes in the lung.When the oral microbiota is unbalanced,the microbial population can be transformed into a pathogenic community that can induce or promote oral and extraoral diseases.Recently,researchers have studied the relationship between the microbiota and lung cancer and found that the microbiome is an environmental factor affecting the occurrence and development of the disease.Poor oral health caused by an imbalance of the oral microbiota increases the risk of lung cancer.Notably,oral microorganisms,such as Porphyromonas gingivalis,Streptococcus,Fusobacterium nucleatum,Veillonella,Aggregatibacter actinomycetemcomitans,and Haemophilus influenzae,are the main oral carcinogenic microorganisms.The mechanisms whereby these oral microbes induce the occurrence and development of lung cancer are mainly through(1)disrupting the biological barrier formed by epithelial cells or through direct inhalation leading to colonization of the lungs,stimulate long-term chronic inflammation,and provide a favorable environment for lung cancer cell proliferation and mutations,or through the colonization of the intestinal tract to affect the function of intestinal flora and promote the growth and proliferation of lung cancer cells.(2)Oral microorganisms can lead to imbalanced immune homeostasis regulation or eliminate the mechanisms of immunity against tumors and promote the escape of tumor cells.They can also lead to pulmonary immune deficiencies and create conditions for the occurrence of cancer.(3)Oral microorganis

关 键 词：口腔微生物组 肺癌 生物标志物 

分 类 号：R734.2[医药卫生—肿瘤]