基于化学诱导系统chemiDroplet实现相分离的可逆调控  

Reversible manipulation of liquid-liquid phase separation using a chemical-based chemiDroplet

作　　者：田超 万圣鹏 卢毅 王平 葛欣 方兰 Chao Tian;Shengpeng Wan;Yi Lu;Ping Wang;Xin Ge;Lan Fang(Cancer Center,Shanghai Tenth People’s Hospital,Tongji University School of Medicine,Tongji University,Shanghai 200072,China;Science Center of Nanocatalytic Medicine,Tongji University School of Medicine,Tongji University,Shanghai 200331,China)

机构地区：[1]Cancer Center,Shanghai Tenth People’s Hospital,Tongji University School of Medicine,Tongji University,Shanghai 200072,China [2]Science Center of Nanocatalytic Medicine,Tongji University School of Medicine,Tongji University,Shanghai 200331,China

出　　处：《Science Bulletin》2024年第4期441-444,共4页科学通报（英文版）

基　　金：supported by the National Key Research and Development Program of China(2022YFC3401500,2020YFA0803201,and 2021YFA1302200);the National Natural Science Foundation of China(31830053,31920103007,82341028,82122056,82073153,81972676,31900568,and 32270745);the Natural Science Foundation of Shanghai(23ZR1466500);the Shanghai Municipal Health Commission(2022YQ067);the Fundamental Research Funds for the Central Universities(PA2023000691,PA2023000718,and PA2023000692).

摘　　要：Liquid-liquid phase separation(LLPS)emerges as a general approach for the generation of biomolecular condensates,which play important roles in various biological processes,including chromatin organization,transcription,translation,protein degradation,and signal transduction^([1]).Irregular phase separation is often associated with cancer,neurodegeneration,and other human diseases^([2]).

关 键 词：DISEASES SEPARATION chemi 

分 类 号：Q503[生物学—生物化学]